Detailed information of TA system TA238527

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3756571..3756985
• Replicon: chromosome
• Accession: NZ_CP093405
• Organism: Salmonella enterica subsp. enterica serovar Agona strain R21.1368

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: B5F8Y1
• Locus tag: MOP56_RS18500
• Protein ID: WP_000994221.1
• Coordinates: 3756728..3756985 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3756571..3756949 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOP56_RS18470	3751894..3752391	-	498	WP_000835844.1	Saf-pilin pilus formation protein SafA	-
MOP56_RS18475	3753152..3753856	-	705	Protein_3625	integrase core domain-containing protein	-
MOP56_RS18480	3753940..3754089	+	150	WP_151273333.1	type I toxin-antitoxin system SymE family toxin	-
MOP56_RS18485	3754221..3754499	-	279	WP_077905764.1	hypothetical protein	-
MOP56_RS18490	3754817..3755284	-	468	WP_000828177.1	sugar tyrosine-protein kinase	-
MOP56_RS18495	3756101..3756520	-	420	WP_130549555.1	hypothetical protein	-
-	3756571..3756949	-	379	-	-	Antitoxin
MOP56_RS18500	3756728..3756985	+	258	WP_000994221.1	SymE family type I addiction module toxin	Toxin
MOP56_RS18505	3757052..3757483	-	432	WP_023135248.1	hypothetical protein	-
MOP56_RS18510	3757555..3757971	-	417	WP_001748027.1	DUF2195 family protein	-
MOP56_RS18515	3757968..3758336	-	369	Protein_3633	hypothetical protein	-
MOP56_RS18520	3758335..3758400	+	66	Protein_3634	hypothetical protein	-
MOP56_RS18525	3758650..3758835	-	186	Protein_3635	transposase	-
MOP56_RS18530	3758935..3759606	-	672	WP_000058649.1	ankyrin repeat domain-containing protein	-
MOP56_RS18535	3759622..3760107	-	486	WP_000103455.1	hypothetical protein	-
MOP56_RS18540	3760449..3760685	+	237	WP_130549554.1	hypothetical protein	-
MOP56_RS18545	3760767..3760943	+	177	Protein_3639	phage integrase N-terminal domain-containing protein	-
MOP56_RS18550	3761411..3761773	-	363	WP_001748026.1	Arm DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9356.66 Da
• Isoelectric Point: 5.6373

>T238527 WP_000994221.1 NZ_CP093405:3756728-3756985 [Salmonella enterica subsp. enterica serovar Agona]
MNASGVSVRHINSETCITTCYSQIPSQHLKGDWQEEAGFETGRSVTVKISQGCIVLMADGNEVQKLCEQLYQAERVVKGL
KDVLV

Nucleotide

• Length: 258 bp

>T238527 NZ_LR890381:c4571072-4570539 [Klebsiella pneumoniae]
ATGGAGCAGCAACTGACGATTGAGATGATTGCCGATGCGTTCAGCTACGATATCACTGGATTTGATTGCGGCGAGGAAGC
GCTGAATACGTTTTTAAAAGAGCACCTCAAGCGGCAGCACGATGGACAAATCTTAAGGGGTTATGCGCTGGTCTCCAGGG
ATACCGTTCCCAGGTTGCTGGGTTATTACACCTTATCGGGGAGTTGTTTCGAGCGAGGCATGTTGCCGTCTAAAACTCAG
CAAAAGAAAATCCCGTATCAAAATGCGCCAAGCGTAACCCTCGGGCGGCTGGCCATTGATAAATCTGTTCAGGGGCAGGG
CTGGGGAGAGATGTTGGTTGCCCATGCGATGCGAGTGGTGTGGGGAGCGTCTAAAGCCGTTGGCATCTACGGATTGTTTG
TTGAAGCCCTTAATGAGAAGGCTAAAGCATTCTATCTTCGTCTGGGGTTTATACAGCTCGTGGATGAAAATAGTAACTTA
CTGTTTTATCCGACCAAATCGATTGAACAGCTCTTTACTGACGATGAGTCATAA

Antitoxin

Nucleotide

• Length: 379 bp

>AT238527 NZ_CP093405:c3756949-3756571 [Salmonella enterica subsp. enterica serovar Agona]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCCTGTGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAG
TAACAGGTGGTTATACAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAA
TTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCC
CCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3L1ZDZ2

Antitoxin