Detailed information of TA system TA238505

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3741596..3742010
• Replicon: chromosome
• Accession: NZ_CP093403
• Organism: Salmonella enterica subsp. enterica serovar Agona strain R21.1436

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: B5F8Y1
• Locus tag: MOP57_RS18415
• Protein ID: WP_000994221.1
• Coordinates: 3741753..3742010 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3741596..3741974 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOP57_RS18385	3736919..3737416	-	498	WP_000835844.1	Saf-pilin pilus formation protein SafA	-
MOP57_RS18390	3738177..3738881	-	705	Protein_3607	integrase core domain-containing protein	-
MOP57_RS18395	3738965..3739114	+	150	WP_151273333.1	type I toxin-antitoxin system SymE family toxin	-
MOP57_RS18400	3739246..3739524	-	279	WP_077905764.1	hypothetical protein	-
MOP57_RS18405	3739842..3740309	-	468	WP_000828177.1	sugar tyrosine-protein kinase	-
MOP57_RS18410	3741126..3741545	-	420	WP_130549555.1	hypothetical protein	-
-	3741596..3741974	-	379	-	-	Antitoxin
MOP57_RS18415	3741753..3742010	+	258	WP_000994221.1	SymE family type I addiction module toxin	Toxin
MOP57_RS18420	3742077..3742508	-	432	WP_023135248.1	hypothetical protein	-
MOP57_RS18425	3742580..3742996	-	417	WP_001748027.1	DUF2195 family protein	-
MOP57_RS18430	3742993..3743361	-	369	Protein_3615	hypothetical protein	-
MOP57_RS18435	3743360..3743425	+	66	Protein_3616	hypothetical protein	-
MOP57_RS18440	3743675..3743860	-	186	Protein_3617	transposase	-
MOP57_RS18445	3743960..3744631	-	672	WP_000058649.1	ankyrin repeat domain-containing protein	-
MOP57_RS18450	3744647..3745132	-	486	WP_000103455.1	hypothetical protein	-
MOP57_RS18455	3745474..3745710	+	237	WP_130549554.1	hypothetical protein	-
MOP57_RS18460	3745792..3745968	+	177	Protein_3621	phage integrase N-terminal domain-containing protein	-
MOP57_RS18465	3746436..3746798	-	363	WP_001748026.1	Arm DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9356.66 Da
• Isoelectric Point: 5.6373

>T238505 WP_000994221.1 NZ_CP093403:3741753-3742010 [Salmonella enterica subsp. enterica serovar Agona]
MNASGVSVRHINSETCITTCYSQIPSQHLKGDWQEEAGFETGRSVTVKISQGCIVLMADGNEVQKLCEQLYQAERVVKGL
KDVLV

Nucleotide

• Length: 258 bp

>T238505 NZ_LR890374:722069-722554 [Klebsiella pneumoniae]
ATGATCTTGGCACCAGAACCGCTTCATGCCGGGCATATTCTTACCCCGTTTTGCTGCGGTATAGATTCCATGGATCACTG
GCTGAAACAGCGGGCGATGAAAAATCAGGTTACTGGCGCATCCCGCACCTTTGTCTGCTGCGACGACGCGAAGGTGATGG
CTTACTACTCACTGGCTTCCAGCGCTGTGACGACAAATACTGCGCCGGGTCGTTTTCGCCGCAATATGCCTGACCCGATC
CCGGTTGTGGTACTGGGTCGTCTGGCGGTGGATAAATCACTACATGGGAAAGGTGTCGGGCGGGCCCTGGTACGTGATGC
CGGGCTGCGTGTGATTCAGGTGGCGGAGACTATCGGCATTCGCGGGATGCTGGTTCACGCCCTGTCGGATGAAGCACGGG
ATTTTTACCTGCGGGTGGGGTTTGAGCCGTCGCCGATGGATCCGATGATGTTGATGGTGACGTTGAGGGATTTAGTTAAT
GCCTGA

Antitoxin

Nucleotide

• Length: 379 bp

>AT238505 NZ_CP093403:c3741974-3741596 [Salmonella enterica subsp. enterica serovar Agona]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCCTGTGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAG
TAACAGGTGGTTATACAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAA
TTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCC
CCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3L1ZDZ2

Antitoxin