Detailed information of TA system TA238459

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3717244..3717658
• Replicon: chromosome
• Accession: NZ_CP093400
• Organism: Salmonella enterica subsp. enterica serovar Infantis strain R21.1147

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5I5SV33
• Locus tag: MOP59_RS18280
• Protein ID: WP_023243487.1
• Coordinates: 3717401..3717658 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3717244..3717576 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MOP59_RS18250	3712497..3713060	-	564	WP_023993992.1	Saf-pilin pilus formation protein SafA	-
MOP59_RS18255	3713759..3714460	-	702	Protein_3580	integrase core domain-containing protein	-
MOP59_RS18260	3714513..3714827	+	315	WP_023892102.1	SymE family type I addiction module toxin	-
MOP59_RS18265	3714894..3715172	-	279	WP_077677834.1	hypothetical protein	-
MOP59_RS18270	3715489..3715956	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
MOP59_RS18275	3716774..3717067	-	294	WP_039515457.1	hypothetical protein	-
-	3717244..3717576	-	333	-	-	Antitoxin
MOP59_RS18280	3717401..3717658	+	258	WP_023243487.1	SymE family type I addiction module toxin	Toxin
MOP59_RS18285	3717725..3718069	-	345	WP_023218822.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3695271..3740655	45384
	-	flank	IS/Tn	-	-	3713759..3714037	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9498.73 Da
• Isoelectric Point: 6.2112

>T238459 WP_023243487.1 NZ_CP093400:3717401-3717658 [Salmonella enterica subsp. enterica serovar Infantis]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFETGRSVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T238459 NZ_LR890356:1992449-1992551 [Klebsiella pneumoniae]
GCAAGGCGACTTAGCCTGCATTAATGCCAACTTTTAGCGCACGGCTCTCTCCCAAGAGCCATTTCCCTGGACCGAATACA
GGAATCGTATTCGGTCTCTTTTT

Antitoxin

Nucleotide

• Length: 333 bp

>AT238459 NZ_CP093400:c3717576-3717244 [Salmonella enterica subsp. enterica serovar Infantis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCTCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5I5SV33

Antitoxin