Detailed information of TA system TA238300

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 908756..909170
• Replicon: chromosome
• Accession: NZ_CP093373
• Organism: Salmonella enterica subsp. enterica serovar Infantis strain 423_13

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5I5SV33
• Locus tag: MNU28_RS04245
• Protein ID: WP_023243487.1
• Coordinates: 908756..909013 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	908838..909170 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MNU28_RS04240	908349..908573	+	225	WP_243409783.1	hypothetical protein	-
MNU28_RS04245	908756..909013	-	258	WP_023243487.1	SymE family type I addiction module toxin	Toxin
-	908838..909170	+	333	-	-	Antitoxin
MNU28_RS04250	909347..909640	+	294	WP_039515457.1	hypothetical protein	-
MNU28_RS04255	910457..910909	+	453	WP_247247464.1	sugar tyrosine-protein kinase	-
MNU28_RS04260	911240..911518	+	279	WP_077677834.1	hypothetical protein	-
MNU28_RS04265	911585..911899	-	315	WP_023892102.1	SymE family type I addiction module toxin	-
MNU28_RS04270	911952..912653	+	702	Protein_826	integrase core domain-containing protein	-
MNU28_RS04275	913352..913915	+	564	WP_023993992.1	Saf-pilin pilus formation protein SafA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	886139..931873	45734
	-	flank	IS/Tn	-	-	912375..912653	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9498.73 Da
• Isoelectric Point: 6.2112

>T238300 WP_023243487.1 NZ_CP093373:c909013-908756 [Salmonella enterica subsp. enterica serovar Infantis]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFETGRSVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T238300 NZ_LR890299:c3074124-3073813 [Escherichia coli]
ATGCTCTTCATCGAAACGGAAATTTTTACTGAAGATGTTCAAAAACTGCTGACCGACGATGAATTCAGTCGTTTTCAGTT
TTTCCTGGCCTTGAATCCTGACTATGGTGAGGTAATACCTGAAACTGGTGGGTTAAGAAAGGTTCGATGGGTGTCAGGAG
GAAAGGGGAAACGTGCTGGTGTCAGGGTTATTTACTTTCATCAGGTTAAACATTATGAGATCAGATTACTGCTTATTTAT
CGTAAGGGTATTAAAGATGATCTGTCTCCCCAGGAAAAAGCAATGCTCCGGTTGTTAAATACGAGGTGGTAA

Antitoxin

Nucleotide

• Length: 333 bp

>AT238300 NZ_CP093373:908838-909170 [Salmonella enterica subsp. enterica serovar Infantis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCTCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5I5SV33

Antitoxin