238273

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-rdlD/SymE(toxin)
Location 829861..830273 Replicon chromosome
Accession NZ_CP093369
Organism Escherichia coli strain EV36 mutant 5a

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag L0Q35_RS04000 Protein ID WP_000132601.1
Coordinates 829861..830202 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name rdlD
Locus tag -
Coordinates 830197..830273 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L0Q35_RS03990 (827274) 827274..828320 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
L0Q35_RS03995 (828320) 828320..829699 - 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
L0Q35_RS04000 (829861) 829861..830202 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- (830197) 830197..830273 + 77 NuclAT_5 - Antitoxin
- (830197) 830197..830273 + 77 NuclAT_5 - Antitoxin
- (830197) 830197..830273 + 77 NuclAT_5 - Antitoxin
- (830197) 830197..830273 + 77 NuclAT_5 - Antitoxin
- (830197) 830197..830273 + 77 NuclAT_6 - Antitoxin
- (830197) 830197..830273 + 77 NuclAT_6 - Antitoxin
- (830197) 830197..830273 + 77 NuclAT_6 - Antitoxin
- (830197) 830197..830273 + 77 NuclAT_6 - Antitoxin
L0Q35_RS04005 (830430) 830430..831824 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
L0Q35_RS04010 (831821) 831821..833410 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 822776..831824 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T238273 WP_000132601.1 NZ_CP093369:c830202-829861 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

>T238273 NZ_LR890291:792918-793328 [Klebsiella pneumoniae]
GTGGTCCTGTGGCAATCTGATCTCCGTATCTCCTGGCGCGCGCAGTGGTTTTCCCTGCTGCTTCACGGCGTGGTGGCGGC
CCTGGTGCTGTTGGTTCCCTGGCCGCTGAGCTATACCCCGATCTGGCTGCTGCTGCTGTCGCTGGTGGTCTTCGACTGCG
TGCGCAGCCAGCGGCGGATCCATGCCCGTCGCGGGGAGATAAAACTGCTCACCGATTCCCGTCTTCGCTGGCAAAACGCC
GAATGGGAGATCCTCGGGACGCCGTGGGTTATCAATAGCGGTATGCTGCTGCGTTTGCGCCATGTCGATACCCGGCGCGG
ACAGCATCTTTGGCTGGCGGCGGACAGCATGGACGCCGGAGAGTGGCGCGATCTGCGCCGGCTGGTGCTGCAAAAACCGG
CGCAGGAGTAA

Antitoxin


Download         Length: 77 bp

>AT238273 NZ_CP093369:830197-830273 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References