Detailed information of TA system TA236747

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3625337..3625757
• Replicon: chromosome
• Accession: NZ_CP092627
• Organism: Salmonella enterica subsp. enterica serovar Thompson strain MFDS1011657

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A8E7RAJ3
• Locus tag: MJ899_RS17870
• Protein ID: WP_000994215.1
• Coordinates: 3625494..3625757 (+)
• Length: 88 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3625337..3625747 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MJ899_RS17830	3620630..3621370	-	741	WP_017465813.1	pili assembly chaperone SafB	-
MJ899_RS17835	3621445..3621942	-	498	WP_017465814.1	hypothetical protein	-
MJ899_RS17840	3622075..3622569	-	495	WP_017465815.1	hypothetical protein	-
MJ899_RS17845	3623364..3624065	-	702	Protein_3493	integrase core domain-containing protein	-
MJ899_RS17850	3624118..3624291	+	174	WP_001531381.1	hypothetical protein	-
MJ899_RS17855	3624356..3624823	-	468	WP_001284951.1	Imm42 family immunity protein	-
MJ899_RS17860	3624816..3625124	-	309	WP_166427842.1	hypothetical protein	-
MJ899_RS17865	3625115..3625252	-	138	WP_231391191.1	hypothetical protein	-
-	3625337..3625747	-	411	-	-	Antitoxin
MJ899_RS17870	3625494..3625757	+	264	WP_000994215.1	hypothetical protein	Toxin
MJ899_RS17875	3625804..3626238	-	435	WP_000789494.1	hypothetical protein	-
MJ899_RS17880	3626235..3627539	-	1305	Protein_3500	RHS repeat-associated core domain-containing protein	-
MJ899_RS17885	3627676..3628140	-	465	WP_223227916.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3613555..3656928	43373

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Fido domain (6-90)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9458.71 Da
• Isoelectric Point: 6.4458

>T236747 WP_000994215.1 NZ_CP092627:3625494-3625757 [Salmonella enterica subsp. enterica serovar Thompson]
MNASGASVRHINSETCMTTCYSQIPSGDCQEEAGFETGASVVVKISERGLILIAETDEVRDLRKELYQVKKSMKHIKAGV
NNVVNGN

Nucleotide

• Length: 264 bp

>T236747 NZ_LR735432:1017924-1018319 [Staphylococcus epidermidis]
ATGCAAAGCACTAAATATTTAACTGAAAAACAAGTGATTGCCATTAATGTAAAAGCAATACAAGATTTCTCACCAAAAGA
ACAAGTTGGTGTTAAAGTTCCAGAAGTTCTTAATGCTACTATTGAAGGAGTTAAACAATCATTCGGTGGAGTTGAACTAT
ATGAAACAATCGAGAGAAAAGCAGCTTTTATATATAGAAATATAGCTCAAAAGCACGCATTCCATAATGCGAATAAAAGA
ACAGCTTTTACATCTATGGTAATATTTTTGAAGTTAAATAGTATTAATTTTGAATGCACTCAAGATGAAGCGGTTCAGTT
TACTTTAAGAGTAGTAAACGACAAAAATCTTACTCTTGAGGGAATTGAGACATGGATCAAGAGGCATTGTAAATAA

Antitoxin

Nucleotide

• Length: 411 bp

>AT236747 NZ_CP092627:c3625747-3625337 [Salmonella enterica subsp. enterica serovar Thompson]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCATCCGTTTCTGCAATCAGGATCAAACCCCGCTCGGAGATCTTCACAACAACGCTCGCCCCGGTCTCAAATCCCGCTT
CTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCG
CCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAG
CGAGTATGGGCGCGACATCCTGGCACTGAGCCCCCCTCTCCCCGGCCAGCTCCGGGCGGTGATGAGCAACCGGCTGCCGG
GGCCGTATTTT

Structures

Antitoxin