Detailed information of TA system TA235827

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 1072391..1072642
• Replicon: chromosome
• Accession: NZ_CP092258
• Organism: Salmonella enterica subsp. enterica serovar Indiana strain 15

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: MF259_RS04895
• Protein ID: WP_131166435.1
• Coordinates: 1072391..1072642 (-)
• Length: 84 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	1072401..1072626 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MF259_RS04875	1069747..1070355	+	609	WP_053505599.1	hypothetical protein	-
MF259_RS04880	1070498..1070635	-	138	WP_023227287.1	hypothetical protein	-
MF259_RS04885	1070655..1071500	+	846	Protein_955	RHS repeat-associated core domain-containing protein	-
MF259_RS04890	1071881..1072345	+	465	WP_127201574.1	hypothetical protein	-
MF259_RS04895	1072391..1072642	-	252	WP_131166435.1	SymE family type I addiction module toxin	Toxin
-	1072401..1072626	+	226	-	-	Antitoxin
MF259_RS04900	1072706..1073407	+	702	Protein_958	integrase core domain-containing protein	-
MF259_RS04905	1074175..1074669	+	495	WP_051129373.1	hypothetical protein	-
MF259_RS04910	1074802..1075299	+	498	WP_051129374.1	Saf-pilin pilus formation protein SafA	-
MF259_RS04915	1075374..1076114	+	741	WP_051129375.1	pili assembly chaperone SafB	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1049687..1093248	43561
	-	flank	IS/Tn	-	-	1073129..1073407	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (10-48)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9451.82 Da
• Isoelectric Point: 8.0365

>T235827 WP_131166435.1 NZ_CP092258:c1072642-1072391 [Salmonella enterica subsp. enterica serovar Indiana]
MRDTYKTHMTTYYSRIPSLHLKGDWLAEAGFDTGASVTVKISEGCLTLIVETDEVRDLRRELYQVKKSMKHIKAGVYDVV
NGN

Nucleotide

• Length: 252 bp

>T235827 NZ_LR134385:1118174-1118983 [Gardnerella vaginalis]
ATGGGTAAGTGTGATTTTGCTATGGTTATAGAAGATTTTAGCGAAGAGTATTTTACTCACTGTTTGTTAAGAAATTTACG
TTCTTTACAAATGTATAAGCATGCAGATTTGCATCCTAAGGCGGTTTTACTCGGTGGTCAAAGTGGTGCTGGCAAAACGA
CCATTCATGTAATAAAACAAAAAGAATTTAACGGTAACATAATAATCCTTGATGCTGATAGCTATAGGACTCAACACCCT
TATTATTGCGAGTTGCTTGATAAATACGGTAAAGAAAGTGTTAAATATACGAGTGCTTTTTCAGCAAAAATGGTGAGAAG
CTTAATTGATGAGTTAAGTTCTAAAAAATATAATCTCATAATTGAAGGTACTTTGCGCAGTGTTGAAGTTCCTAGTAGTA
CTGCGAAAATGTTGATAGATCGTGGTTACCGTATTTCTCTTGCTGTCATTGCAACAAAACCTGAATTGTCATGGATCAGT
ACGCTGATTCGCTACAGGGAAATGTATTTGGAAGATCCTAAAAGTGCTAGGGCAACTCCTAAGGATCATCACGACAATAT
TGTGAACAATATAGTAGATAACTTGTTGAAATTAGAACAATCGAAAATATTTGACAGAATTCAGATTTACAAGCGAGACG
AAAAATGTATATATGATTCTGATTCGTATAAAAATAGTCCAAATATTACAGCAGCTAGTGTTCTTAAGGAAGTGCTCTTT
GGCAAGAAAACTATTGATGAGAAAAAGTTGATTTGCCACGCTAAGAATAGGTTGAATGAACTAGACAAGTTGATAGATAA
AAGTTTGTAG

Antitoxin

Nucleotide

• Length: 226 bp

>AT235827 NZ_CP092258:1072401-1072626 [Salmonella enterica subsp. enterica serovar Indiana]
TTCACCACATCATATACCCCCGCCTTAATGTGCTTCATCGACTTTTTCACCTGATAAAGCTCCCTCCGTAGATCCCTCAC
TTCGTCTGTCTCCACAATCAGAGTCAAACACCCTTCGGAGATCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCAGGCTGGGGATGCGCGAGTAATAGGTGGTCATGTGGGTTT

Structures

Antitoxin