Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 1860670..1860852 Replicon chromosome
Accession NZ_CP092052
Organism Staphylococcus aureus strain USA300

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag AH5667_RS09035 Protein ID WP_001801861.1
Coordinates 1860670..1860765 (+) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 1860793..1860852 (-)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
AH5667_RS08995 1856330..1856956 + 627 Protein_1771 hypothetical protein -
AH5667_RS09000 1856997..1857341 + 345 WP_000627551.1 DUF3969 family protein -
AH5667_RS09005 1857439..1857990 + 552 WP_000414205.1 hypothetical protein -
AH5667_RS09010 1858208..1858849 - 642 WP_000494956.1 ImmA/IrrE family metallo-endopeptidase -
AH5667_RS09015 1858963..1859148 - 186 WP_000809857.1 hypothetical protein -
AH5667_RS09020 1859150..1859326 - 177 WP_000375476.1 hypothetical protein -
AH5667_RS09025 1859337..1859720 - 384 WP_000070811.1 hypothetical protein -
AH5667_RS09030 1860324..1860467 - 144 WP_001549059.1 transposase -
AH5667_RS09035 1860670..1860765 + 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
- 1860793..1860852 - 60 - - Antitoxin
AH5667_RS09040 1860888..1860989 + 102 WP_001791893.1 hypothetical protein -
AH5667_RS09045 1860967..1861143 - 177 Protein_1781 transposase -
AH5667_RS09050 1861337..1861714 - 378 WP_001037045.1 DUF1433 domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - lukD / hlgA 1853770..1893941 40171


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin-antitoxin system, RelE/ParE toxin family

(6-100)


Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T235596 WP_001801861.1 NZ_CP092052:1860670-1860765 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T235596 NZ_LR134309:c5141450-5141103 [Pseudomonas aeruginosa]
ATGTCCCCGGTCGTCATTCGTTTTACTGATACCGCAGAGCAAAGCATCGAAGACCAAGTCCACCACTTGGCTCCATTCCA
AGGTGAACAGGCTGCATTCCAGTCAGTACTGAGCCTTTTGGATGAGATTGAAGAGAAGATTTCACTTGCACCTAAAGGTT
ACCCAGTCAGCCAGCAGGCGAGTCTTCTGGGGGTGCTGAGCTATCGCGAGCTTAATACCGGCCCCTATCGTGTTTTTTAC
GAATTCCACGAAGAGCAAGGCGAGGCGGCAGTGATCTTGGTTCTGCGACAGAAGCAGAGCGTTGAGCAGCAATTGATCCG
CTACTGCTTGGTGGGGCCAATCGAGTGA

Antitoxin


Download         Length: 60 bp

>AT235596 NZ_CP092052:c1860852-1860793 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References