Detailed information of TA system TA235550

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 909065..909479
• Replicon: chromosome
• Accession: NZ_CP092040
• Organism: Salmonella enterica subsp. enterica serovar Infantis strain S19

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5I5SV33
• Locus tag: MCR19_RS04255
• Protein ID: WP_023243487.1
• Coordinates: 909065..909322 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	909147..909479 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MCR19_RS04250	908654..908998	+	345	WP_023218822.1	hypothetical protein	-
MCR19_RS04255	909065..909322	-	258	WP_023243487.1	SymE family type I addiction module toxin	Toxin
-	909147..909479	+	333	-	-	Antitoxin
MCR19_RS04260	909656..909949	+	294	WP_039515457.1	hypothetical protein	-
MCR19_RS04265	910767..911234	+	468	WP_000828178.1	sugar tyrosine-protein kinase	-
MCR19_RS04270	911551..911829	+	279	WP_077677834.1	hypothetical protein	-
MCR19_RS04275	911896..912210	-	315	WP_023892102.1	SymE family type I addiction module toxin	-
MCR19_RS04280	912263..912964	+	702	Protein_826	integrase core domain-containing protein	-
MCR19_RS04285	913663..914226	+	564	WP_023993992.1	Saf-pilin pilus formation protein SafA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	886441..930306	43865
	-	flank	IS/Tn	-	-	912686..912964	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9498.73 Da
• Isoelectric Point: 6.2112

>T235550 WP_023243487.1 NZ_CP092040:c909322-909065 [Salmonella enterica subsp. enterica serovar Infantis]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFETGRSVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T235550 NZ_LR134303:c3772197-3771781 [Shewanella putrefaciens]
TTGAATGACATTATTATCAACAAAATAGCAACCATCAAACGCTGTATAAAACGCATCCAACAAGTTTATGGTGATGGCAG
CATGTTCAAACAAGACTTCACCCTGCAAGATAGCGTTATCCTCAATTTACAACGCTGCTGCGAAGCCAGTATCGACATAG
CAAACCATATTAACCGCCAACAACAACTGGGTATCCCCCAAAGTAGCCGTGATAGCTTTACACTACTTTCACAAAATAAA
ATAATTAATCAGCAGCTTGCAGACAACTTAAAGAAGATGGTTGGCCTAAGAAACATCGCAGTACATGACTATCAAGAACT
CAACCTCGATATCGTTGTGCATGTTGTACAGCATCATCTTGAGGATTTTGAGCAATTTATTGAAGTGATAAAATTTTGTC
CAAGAATGCGTTATTGA

Antitoxin

Nucleotide

• Length: 333 bp

>AT235550 NZ_CP092040:909147-909479 [Salmonella enterica subsp. enterica serovar Infantis]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCTCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5I5SV33

Antitoxin