Detailed information of TA system TA235481

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3654338..3654752
• Replicon: chromosome
• Accession: NZ_CP092012
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain N12-0259

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V3U6I8
• Locus tag: MA624_RS17945
• Protein ID: WP_023203422.1
• Coordinates: 3654495..3654752 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3654338..3654670 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MA624_RS17915	3649595..3650092	-	498	WP_058654878.1	Saf-pilin pilus formation protein SafA	-
MA624_RS17920	3650853..3651557	-	705	Protein_3508	integrase core domain-containing protein	-
MA624_RS17925	3651610..3651846	+	237	Protein_3509	SymE family type I addiction module toxin	-
MA624_RS17930	3651991..3652269	-	279	WP_012664366.1	hypothetical protein	-
MA624_RS17935	3652587..3653054	-	468	WP_000828182.1	sugar tyrosine-protein kinase	-
MA624_RS17940	3653147..3653422	-	276	WP_223163371.1	hypothetical protein	-
-	3654338..3654670	-	333	-	-	Antitoxin
MA624_RS17945	3654495..3654752	+	258	WP_023203422.1	SymE family type I addiction module toxin	Toxin
MA624_RS17950	3654811..3655119	-	309	WP_023203423.1	hypothetical protein	-
MA624_RS17955	3655138..3655545	-	408	WP_024146273.1	DUF4329 domain-containing protein	-
MA624_RS17960	3655906..3656427	-	522	WP_023203424.1	SMI1/KNR4 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3632362..3688329	55967
	-	flank	IS/Tn	-	-	3650853..3651134	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.71 Da
• Isoelectric Point: 7.2431

>T235481 WP_023203422.1 NZ_CP092012:3654495-3654752 [Salmonella enterica subsp. enterica serovar Kentucky]
MNASGASVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T235481 NZ_LR134293:2058473-2058745 [Streptococcus canis]
ATGTTACAACTCGTTACGACCAATCAATTCCGTAAAGATGTCAAGCGTGCAAAAAAGCGTGGACTCAACCTCAAGAAATT
AGAAGCCGTGTTGGACCCATTACAGAAGGAAGAAACTCTCGATGAAAAACACAGAGACCATGCCCTTGTTGGAAATTATA
TGGGATTTAGAGAGTGCCACATTGAACCTGACTGGCTTTTAGTTTATGCCATAGATAAGGGACAACTTATTCTGACAGCA
TCAAGAACTGGTTCTCACTCCGACTTATTCTAA

Antitoxin

Nucleotide

• Length: 333 bp

>AT235481 NZ_CP092012:c3654670-3654338 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V3U6I8

Antitoxin