Detailed information of TA system TA235460

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3619985..3620399
• Replicon: chromosome
• Accession: NZ_CP092009
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain N12-0931

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V3U6I8
• Locus tag: MA811_RS17700
• Protein ID: WP_023203422.1
• Coordinates: 3620142..3620399 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3619985..3620317 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MA811_RS17670	3615242..3615739	-	498	WP_058654878.1	Saf-pilin pilus formation protein SafA	-
MA811_RS17675	3616500..3617204	-	705	Protein_3460	integrase core domain-containing protein	-
MA811_RS17680	3617257..3617493	+	237	Protein_3461	SymE family type I addiction module toxin	-
MA811_RS17685	3617638..3617916	-	279	WP_012664366.1	hypothetical protein	-
MA811_RS17690	3618234..3618701	-	468	WP_000828182.1	sugar tyrosine-protein kinase	-
MA811_RS17695	3618794..3619069	-	276	WP_223163371.1	hypothetical protein	-
-	3619985..3620317	-	333	-	-	Antitoxin
MA811_RS17700	3620142..3620399	+	258	WP_023203422.1	SymE family type I addiction module toxin	Toxin
MA811_RS17705	3620458..3620766	-	309	WP_023203423.1	hypothetical protein	-
MA811_RS17710	3620785..3621192	-	408	WP_024146273.1	DUF4329 domain-containing protein	-
MA811_RS17715	3621553..3622074	-	522	WP_023203424.1	SMI1/KNR4 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3598009..3652487	54478
	-	flank	IS/Tn	-	-	3616500..3616781	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.71 Da
• Isoelectric Point: 7.2431

>T235460 WP_023203422.1 NZ_CP092009:3620142-3620399 [Salmonella enterica subsp. enterica serovar Kentucky]
MNASGASVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T235460 NZ_LR134274:799446-799799 [Streptococcus salivarius]
ATGTATCCTATTCATTTTTATAAAGATAGAAATGGACATGAACCTGTTAGAGAGTATATTGAAACATTATCTATGAATTC
AAGTAAAGATTCTAGAATTAAATTACATAAAATTCAAGACTACCTGACTATGTTAAAAAATAGAGGAACCATGATTGGTG
AACCATTCATTAAACATTTGGAAGGAGAGATTTGGGAACTAAGACCCTTAAGAGATAGAATTTTATTTGCAGCATGGCTA
GATGATGGTTTTATTTTGCTTCATCATTTTGTGAAAAAGACACAAAAGACTCCAAGACGTGAGCTGATGAAGGCTCAAAA
GGCTTTAGATGATATTAGAAAGCGAGGATTGTAA

Antitoxin

Nucleotide

• Length: 333 bp

>AT235460 NZ_CP092009:c3620317-3619985 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V3U6I8

Antitoxin