Detailed information of TA system TA235418

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3588625..3589039
• Replicon: chromosome
• Accession: NZ_CP091999
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain N16-1393

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V3U6I8
• Locus tag: MA802_RS17520
• Protein ID: WP_023203422.1
• Coordinates: 3588782..3589039 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3588625..3588957 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MA802_RS17490	3583882..3584379	-	498	WP_058654878.1	Saf-pilin pilus formation protein SafA	-
MA802_RS17495	3585140..3585844	-	705	Protein_3422	integrase core domain-containing protein	-
MA802_RS17500	3585897..3586133	+	237	Protein_3423	SymE family type I addiction module toxin	-
MA802_RS17505	3586278..3586556	-	279	WP_012664366.1	hypothetical protein	-
MA802_RS17510	3586874..3587341	-	468	WP_000828182.1	sugar tyrosine-protein kinase	-
MA802_RS17515	3587434..3587709	-	276	WP_223163371.1	hypothetical protein	-
-	3588625..3588957	-	333	-	-	Antitoxin
MA802_RS17520	3588782..3589039	+	258	WP_023203422.1	SymE family type I addiction module toxin	Toxin
MA802_RS17525	3589098..3589406	-	309	WP_023203423.1	hypothetical protein	-
MA802_RS17530	3589425..3589832	-	408	WP_024146273.1	DUF4329 domain-containing protein	-
MA802_RS17535	3590193..3590714	-	522	WP_023203424.1	SMI1/KNR4 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	blaCTX-M-14b	-	3566649..3625470	58821
	-	flank	IS/Tn	-	-	3585140..3585421	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.71 Da
• Isoelectric Point: 7.2431

>T235418 WP_023203422.1 NZ_CP091999:3588782-3589039 [Salmonella enterica subsp. enterica serovar Kentucky]
MNASGASVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T235418 NZ_LR134248:3567514-3567792 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAA
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTATTTGGGTAA

Antitoxin

Nucleotide

• Length: 333 bp

>AT235418 NZ_CP091999:c3588957-3588625 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V3U6I8

Antitoxin