Detailed information of TA system TA235398

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3656940..3657354
• Replicon: chromosome
• Accession: NZ_CP091998
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain N18-2092

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V3U6I8
• Locus tag: MA840_RS17955
• Protein ID: WP_023203422.1
• Coordinates: 3657097..3657354 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3656940..3657272 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MA840_RS17925	3652197..3652694	-	498	WP_058654878.1	Saf-pilin pilus formation protein SafA	-
MA840_RS17930	3653455..3654159	-	705	Protein_3514	integrase core domain-containing protein	-
MA840_RS17935	3654212..3654448	+	237	Protein_3515	SymE family type I addiction module toxin	-
MA840_RS17940	3654593..3654871	-	279	WP_012664366.1	hypothetical protein	-
MA840_RS17945	3655189..3655656	-	468	WP_000828182.1	sugar tyrosine-protein kinase	-
MA840_RS17950	3655749..3656024	-	276	WP_223163371.1	hypothetical protein	-
-	3656940..3657272	-	333	-	-	Antitoxin
MA840_RS17955	3657097..3657354	+	258	WP_023203422.1	SymE family type I addiction module toxin	Toxin
MA840_RS17960	3657413..3657721	-	309	WP_023203423.1	hypothetical protein	-
MA840_RS17965	3657740..3658147	-	408	WP_024146273.1	DUF4329 domain-containing protein	-
MA840_RS17970	3658508..3659029	-	522	WP_023203424.1	SMI1/KNR4 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	3653455..3653736	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.71 Da
• Isoelectric Point: 7.2431

>T235398 WP_023203422.1 NZ_CP091998:3657097-3657354 [Salmonella enterica subsp. enterica serovar Kentucky]
MNASGASVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T235398 NZ_LR134247:3901431-3901772 [Escherichia coli]
ATGAAAACTTTACCTGCAACAACTCAGCGGGCGGTGAAGCCCTGCCTGTCACCCGTGGCTGTCTGGCAAATGTTACTGAC
ACGTCTGCTGGAACAGCACTATGGTCTGACAATAAACGACACGCCATTCTGCAATGAGGCTGTGATTAAGGAACACATCG
ATGCCGGTATCACCCTAGCCGATGCCGTGAATTTTCTGGTAGAAAAATACGAGCTGGTTCGTATCGACAGGAAGGGATTT
AGCTGGCAGGAACAATCTCCTTATCTCCGGGCTGCAGACATTCTGCGAGCGCGGCAGGCAACTGGCTTGTTGCGGCAAAG
CCGTAACAACGTAGTACGATGA

Antitoxin

Nucleotide

• Length: 333 bp

>AT235398 NZ_CP091998:c3657272-3656940 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V3U6I8

Antitoxin