Detailed information of TA system TA235364

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 371444..371858
• Replicon: chromosome
• Accession: NZ_CP091997
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain N20-2289

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V3U6I8
• Locus tag: MA641_RS01710
• Protein ID: WP_023203422.1
• Coordinates: 371444..371701 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	371526..371858 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
MA641_RS01695	369769..370290	+	522	WP_023203424.1	SMI1/KNR4 family protein	-
MA641_RS01700	370651..371058	+	408	WP_024146273.1	DUF4329 domain-containing protein	-
MA641_RS01705	371077..371385	+	309	WP_023203423.1	hypothetical protein	-
MA641_RS01710	371444..371701	-	258	WP_023203422.1	SymE family type I addiction module toxin	Toxin
-	371526..371858	+	333	-	-	Antitoxin
MA641_RS01715	372774..373049	+	276	WP_223163371.1	hypothetical protein	-
MA641_RS01720	373142..373609	+	468	WP_000828182.1	sugar tyrosine-protein kinase	-
MA641_RS01725	373927..374205	+	279	WP_012664366.1	hypothetical protein	-
MA641_RS01730	374350..374586	-	237	Protein_338	SymE family type I addiction module toxin	-
MA641_RS01735	374639..375343	+	705	Protein_339	integrase core domain-containing protein	-
MA641_RS01740	376104..376601	+	498	WP_058654878.1	Saf-pilin pilus formation protein SafA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	360303..394572	34269
	-	flank	IS/Tn	-	-	375062..375343	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.71 Da
• Isoelectric Point: 7.2431

>T235364 WP_023203422.1 NZ_CP091997:c371701-371444 [Salmonella enterica subsp. enterica serovar Kentucky]
MNASGASVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T235364 NZ_LR134240:3721983-3722261 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATATTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATACTTTACCGCTTCCAGCTGTTTATAAAGACCATCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Nucleotide

• Length: 333 bp

>AT235364 NZ_CP091997:371526-371858 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V3U6I8

Antitoxin