Detailed information of TA system TA234964

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3649702..3650122
• Replicon: chromosome
• Accession: NZ_CP091878
• Organism: Salmonella enterica subsp. enterica serovar Tennessee strain 21-SA00318-0

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3G3E224
• Locus tag: L8I56_RS17850
• Protein ID: WP_000994213.1
• Coordinates: 3649859..3650122 (+)
• Length: 88 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3649702..3650112 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L8I56_RS17820	3644957..3645454	-	498	WP_000835844.1	Saf-pilin pilus formation protein SafA	-
L8I56_RS17825	3646215..3646919	-	705	Protein_3495	integrase core domain-containing protein	-
L8I56_RS17830	3646972..3647286	+	315	WP_001539118.1	SymE family type I addiction module toxin	-
L8I56_RS17835	3647352..3647630	-	279	WP_077905245.1	hypothetical protein	-
L8I56_RS17840	3647947..3648414	-	468	WP_000828176.1	hypothetical protein	-
L8I56_RS17845	3648507..3648731	-	225	WP_001538166.1	hypothetical protein	-
-	3649702..3650112	-	411	-	-	Antitoxin
L8I56_RS17850	3649859..3650122	+	264	WP_000994213.1	hypothetical protein	Toxin
L8I56_RS17855	3650176..3650487	-	312	WP_000849719.1	hypothetical protein	-
L8I56_RS17860	3650500..3650943	-	444	WP_217903324.1	HNH endonuclease	-
L8I56_RS17865	3651125..3651514	-	390	WP_000264306.1	Imm50 family immunity protein	-
L8I56_RS17870	3651529..3652111	-	583	Protein_3504	HNH/endonuclease VII fold putative polymorphic toxin	-
L8I56_RS17875	3652248..3652514	-	267	WP_029412312.1	MafI family immunity protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3637062..3687213	50151

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin-antitoxin system, RelE/ParE toxin family (5-83)

Sequences

Toxin

Protein

• Length: 88 a.a.
• Molecular weight: 9537.84 Da
• Isoelectric Point: 5.6832

>T234964 WP_000994213.1 NZ_CP091878:3649859-3650122 [Salmonella enterica subsp. enterica serovar Tennessee]
MNASGASVRHINSETCMITCYSQIPSGDCQEEAGFETGRSVTVKISEGCLILMAETDEVRELRKELYQVKKSMKHIKAGV
NDVVNGN

Nucleotide

• Length: 264 bp

>T234964 NZ_LR134161:861280-861567 [Yersinia enterocolitica subsp. enterocolitica]
ATGATTTATAAAGTAAAATTTAGAAGTGATGCCCTAAAGGAATGGGGAAAGATAGACAAAGTTATTCAACAGCAGTTTGC
TAAAAAACTCAAAAAATGTTGTGAAAATCCTCATATTCCATCAGCAAAATTACGCGGATTATCAGACTGCTATAAAATAA
AATTACGGGCATCTGGTTTTAGGTTAGTTTATCAAGTTATTGAAGATTGTTTAGTTATCGCCGTGGTTGCCGTCGGCAAA
CGCGAACGCAGTGATGTTTATAACCTCGCCAGTGAACGGTTACGATAA

Antitoxin

Nucleotide

• Length: 411 bp

>AT234964 NZ_CP091878:c3650112-3649702 [Salmonella enterica subsp. enterica serovar Tennessee]
TTCACCACATCATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGCTCCCTCAC
TTCGTCCGTCTCAGCCATCAGGATCAAACATCCCTCGGAGATCTTCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTT
CTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGTGATCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGGCG
CCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAG
CGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTGCCGG
GGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3G3E224

Antitoxin