Detailed information of TA system TA234187

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3496208..3496600
• Replicon: chromosome
• Accession: NZ_CP091640
• Organism: Salmonella enterica strain 965

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V9S8T1
• Locus tag: L5503_RS16860
• Protein ID: WP_000994223.1
• Coordinates: 3496355..3496600 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3496208..3496564 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5503_RS16830	3491460..3491957	-	498	WP_165963407.1	pilus assembly protein	-
L5503_RS16835	3492719..3493423	-	705	Protein_3294	integrase core domain-containing protein	-
L5503_RS16840	3493476..3493790	+	315	WP_133322996.1	SymE family type I addiction module toxin	-
L5503_RS16845	3493857..3494135	-	279	WP_133323248.1	hypothetical protein	-
L5503_RS16850	3494453..3494920	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
L5503_RS16855	3495738..3496157	-	420	WP_131040133.1	hypothetical protein	-
-	3496208..3496564	-	357	-	-	Antitoxin
L5503_RS16860	3496355..3496600	+	246	WP_000994223.1	hypothetical protein	Toxin
L5503_RS16865	3496667..3497209	-	543	WP_079984650.1	hypothetical protein	-
L5503_RS16870	3497209..3501315	-	4107	WP_133322998.1	RHS repeat-associated core domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3483555..3497209	13654

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Protein of unknown function DUF1474 (1-98)

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8789.96 Da
• Isoelectric Point: 4.1428

>T234187 WP_000994223.1 NZ_CP091640:3496355-3496600 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

>T234187 NZ_LR027870:860904-861224 [Staphylococcus aureus]
ATGAATTGGGAAATTAAAGATTTAATGTGTGACATTGAAGTGATAAAACAAAAAATTAATGATGTAGCTACCAAACATGC
TTGGTTTGTTGAAGATAGATTTGTAAAAAATGAATTAGAAACAAAACGGGAACATATTAATTTTTCTGCTAGCTATTTAG
AACATCGTATACAAAATGAACATACAGTTGAGTTATTACATGTGTACTTAAAAGAATTCAGTGAACTTATACAAAAATTT
CATGAAATAGAAAAAGCGTCATCAGAGAACTTTGACGAGGAATCAGATGACGCAAAGAATTCAATAAAAGTAGCAGAGTA
A

Antitoxin

Nucleotide

• Length: 357 bp

>AT234187 NZ_CP091640:c3496564-3496208 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V9S8T1

Antitoxin