Detailed information of TA system TA234166

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3496225..3496617
• Replicon: chromosome
• Accession: NZ_CP091636
• Organism: Salmonella enterica strain 1063

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V9S8T1
• Locus tag: L5504_RS16865
• Protein ID: WP_000994223.1
• Coordinates: 3496372..3496617 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3496225..3496581 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5504_RS16835	3491477..3491974	-	498	WP_165963407.1	pilus assembly protein	-
L5504_RS16840	3492736..3493440	-	705	Protein_3295	integrase core domain-containing protein	-
L5504_RS16845	3493493..3493807	+	315	WP_133322996.1	SymE family type I addiction module toxin	-
L5504_RS16850	3493874..3494152	-	279	WP_133323248.1	hypothetical protein	-
L5504_RS16855	3494470..3494937	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
L5504_RS16860	3495755..3496174	-	420	WP_131040133.1	hypothetical protein	-
-	3496225..3496581	-	357	-	-	Antitoxin
L5504_RS16865	3496372..3496617	+	246	WP_000994223.1	hypothetical protein	Toxin
L5504_RS16870	3496684..3497226	-	543	WP_079984650.1	hypothetical protein	-
L5504_RS16875	3497226..3501332	-	4107	WP_133322998.1	RHS repeat-associated core domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3483572..3497226	13654

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8789.96 Da
• Isoelectric Point: 4.1428

>T234166 WP_000994223.1 NZ_CP091636:3496372-3496617 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

>T234166 NZ_LR027520:c204077-203661 [Thermus thermophilus]
CTGAGGTACCTGCTGGACACCAACGTGGTCTCCGAGGCCGTCAAGCGGCGGCCTCACCCCAAGGTGGTGGCCTTCCTGCG
CCACCTTAAAGTGGGGGAGGCGTACCTCTCCGCCCTCACCTTGGGCGAACTGGTCCAGGGGGTGGCCCGGGCCCCGGAGG
CCCGAAGGGCCATCCTCAGCCGATGGCTCTCGGGGCTGAAGGCGAGCTTCTCGGGGCGGATCCTTCCCCTGGACGCCGAG
GTGATGGAGCTCTGGGGCGAGCTCACCGGAAACGCCATGAGGGAGGGCAAGCCCCTCTCTCCCCTAGACGCCATGCTGGC
GGCCACGGCCCTGCGGCACGGCCTGATCCTGGCCACCCGGAACACCGAGGACTTCCGCCACGTTCCCGTGCCCCTCGTGA
ACCCCTGGGAAGGGTAA

Antitoxin

Nucleotide

• Length: 357 bp

>AT234166 NZ_CP091636:c3496581-3496225 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V9S8T1

Antitoxin