Detailed information of TA system TA234051

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3497040..3497432
• Replicon: chromosome
• Accession: NZ_CP091619
• Organism: Salmonella enterica strain 1473

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V9S8T1
• Locus tag: L5510_RS16870
• Protein ID: WP_000994223.1
• Coordinates: 3497187..3497432 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3497040..3497396 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5510_RS16840	3492292..3492789	-	498	WP_165963407.1	pilus assembly protein	-
L5510_RS16845	3493551..3494255	-	705	Protein_3296	integrase core domain-containing protein	-
L5510_RS16850	3494308..3494622	+	315	WP_133322996.1	SymE family type I addiction module toxin	-
L5510_RS16855	3494689..3494967	-	279	WP_133323248.1	hypothetical protein	-
L5510_RS16860	3495285..3495752	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
L5510_RS16865	3496570..3496989	-	420	WP_131040133.1	hypothetical protein	-
-	3497040..3497396	-	357	-	-	Antitoxin
L5510_RS16870	3497187..3497432	+	246	WP_000994223.1	hypothetical protein	Toxin
L5510_RS16875	3497499..3498041	-	543	WP_079984650.1	hypothetical protein	-
L5510_RS16880	3498041..3502135	-	4095	WP_268956764.1	RHS repeat-associated core domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3484387..3498041	13654

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8789.96 Da
• Isoelectric Point: 4.1428

>T234051 WP_000994223.1 NZ_CP091619:3497187-3497432 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

>T234051 NZ_LR025096:c1062594-1062316 [Escherichia coli]
ATGATTCAAAGGGATATTGAATACTCGGGACAATTTTCAAAGGATGTAAAACTTGCACAAAAGCGTCATAAGGATATGAA
TAAATTGAAATATCTTATGACGCTTCTTATCAATAATGCTTTACCGCTTCCAGCTGTTTATAAAGACCACCCGCTGCAAG
GTTCATGGAAAGGTTATCGCGATGCTCATGTCGAACCGGACTGGATCCTGATTTACAAACTTACCGATAAACTTTTACGA
TTTGAGAGAACTGGAACTCACGCGGCGCTCTTTGGGTAA

Antitoxin

Nucleotide

• Length: 357 bp

>AT234051 NZ_CP091619:c3497396-3497040 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V9S8T1

Antitoxin