Detailed information of TA system TA233971

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3535786..3536178
• Replicon: chromosome
• Accession: NZ_CP091604
• Organism: Salmonella enterica strain 1902

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V9S8T1
• Locus tag: L5514_RS17125
• Protein ID: WP_000994223.1
• Coordinates: 3535933..3536178 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3535786..3536142 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L5514_RS17095	3531038..3531535	-	498	WP_165963407.1	pilus assembly protein	-
L5514_RS17100	3532297..3533001	-	705	Protein_3347	integrase core domain-containing protein	-
L5514_RS17105	3533054..3533368	+	315	WP_133322996.1	SymE family type I addiction module toxin	-
L5514_RS17110	3533435..3533713	-	279	WP_133323248.1	hypothetical protein	-
L5514_RS17115	3534031..3534498	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
L5514_RS17120	3535316..3535735	-	420	WP_131040133.1	hypothetical protein	-
-	3535786..3536142	-	357	-	-	Antitoxin
L5514_RS17125	3535933..3536178	+	246	WP_000994223.1	hypothetical protein	Toxin
L5514_RS17130	3536245..3536787	-	543	WP_079984650.1	hypothetical protein	-
L5514_RS17135	3536787..3540893	-	4107	WP_133322998.1	RHS repeat-associated core domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3523133..3536787	13654

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8789.96 Da
• Isoelectric Point: 4.1428

>T233971 WP_000994223.1 NZ_CP091604:3535933-3536178 [Salmonella enterica]
MNASGVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

>T233971 NZ_LN890477:c5373639-5373220 [Achromobacter xylosoxidans]
ATGATTGTCTTGGATACGAATGTCGTCTCCGAGGCGATGAAGCCCGAACCCAACCCGGCCGTGCGAGCTTGGTTGAATGA
ACAGGTAGCGGAAACCCTCTACCTGTCCAGCGTGACGCTGGCCGAGCTGCTGTTCGGCATCGGCGCGCTGCCGAACGGGA
AACGTAAGAAAGGCCTGGGCGAAGCCCTGGACGGCTTGCTCGAACTGTTCGGCGAGCGGGTGCTGATGTTCGACACCGAA
GCAGCTCGCCATTATGCCGAGCTGGCGGTGAAGGCCCGCACAGCCGGGAAGGGGTTCCCAACACCCGACGGATATATCGG
GGCTATTGCGGCCTCCAAGAGATTTATCGTAGCAACACGCGACACCAGCCCTTTTGAAGCGGCTGGGCTTACTGTTATCA
ATCCTTGGAACCATCAGTAA

Antitoxin

Nucleotide

• Length: 357 bp

>AT233971 NZ_CP091604:c3536142-3535786 [Salmonella enterica]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V9S8T1

Antitoxin