Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) sprA1-sprA1AS/-
Location 179263..179445 Replicon chromosome
Accession NZ_CP091523
Organism Staphylococcus aureus strain N12HSA28

Toxin (Protein)


Gene name sprA1 Uniprot ID -
Locus tag L5471_RS01080 Protein ID WP_001801861.1
Coordinates 179350..179445 (-) Length 32 a.a.

Antitoxin (RNA)


Gene name sprA1AS
Locus tag -
Coordinates 179263..179322 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
L5471_RS01065 178401..178778 + 378 WP_001037045.1 DUF1433 domain-containing protein -
L5471_RS01070 178972..179148 + 177 Protein_174 transposase -
L5471_RS01075 179126..179227 - 102 WP_001791893.1 hypothetical protein -
- 179263..179322 + 60 - - Antitoxin
L5471_RS01080 179350..179445 - 96 WP_001801861.1 type I toxin-antitoxin system Fst family toxin PepA1 Toxin
L5471_RS01085 179648..179791 + 144 WP_001549059.1 transposase -
L5471_RS01090 180395..180778 + 384 WP_000070811.1 hypothetical protein -
L5471_RS01095 180789..180965 + 177 WP_000375477.1 hypothetical protein -
L5471_RS01100 181268..181896 + 629 Protein_180 ImmA/IrrE family metallo-endopeptidase -
L5471_RS01105 182094..182666 - 573 WP_000414202.1 hypothetical protein -
L5471_RS01110 182767..183108 - 342 WP_000627541.1 DUF3969 family protein -
L5471_RS01115 183149..183775 - 627 WP_000669017.1 hypothetical protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - hlgA / lukD 146159..186333 40174


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.



Sequences

Toxin        


Download         Length: 32 a.a.        Molecular weight: 3554.32 Da        Isoelectric Point: 10.4449

>T233483 WP_001801861.1 NZ_CP091523:c179445-179350 [Staphylococcus aureus]
VMLIFVHIIAPVISGCAIAFFSYWLSRRNTK

Download         Length: 96 bp

>T233483 NZ_HG941718:4195879-4196256 [Escherichia coli O25b:H4-ST131]
ATGAACACATTACCCGACACACACGTACGGGAGGCATCGCGCTGCCCGTCTCCCGTCACCATCTGGCAGACACTGCTCAC
CCGACTGCTGGACCAGCACTACGGCCTCACGCTGAATGACACACCGTTCGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTACGAACTGACCAGCCAGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATCAACAGCATTGATATTCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCCGGAA
CAATTACAGAATGGTAAATAACATTACCCAGGGCAAGCATCCGGAGGCAAAACGATGA

Antitoxin


Download         Length: 60 bp

>AT233483 NZ_CP091523:179263-179322 [Staphylococcus aureus]
ACAACGAAAATAAGTATTTACTTATACACCAATCCCCTCACTATTTGCGGTAGTGAGGGG

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure

Antitoxin

Download structure file

References