Detailed information of TA system TA232156

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3884344..3884758
• Replicon: chromosome
• Accession: NZ_CP090929
• Organism: Salmonella enterica subsp. enterica serovar Agona strain R21.2429

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: B5F8Y1
• Locus tag: L1L24_RS19295
• Protein ID: WP_000994221.1
• Coordinates: 3884501..3884758 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3884344..3884722 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
L1L24_RS19265	3879667..3880164	-	498	WP_000835844.1	Saf-pilin pilus formation protein SafA	-
L1L24_RS19270	3880925..3881629	-	705	Protein_3781	integrase core domain-containing protein	-
L1L24_RS19275	3881713..3881862	+	150	WP_151273333.1	type I toxin-antitoxin system SymE family toxin	-
L1L24_RS19280	3881994..3882272	-	279	WP_077905764.1	hypothetical protein	-
L1L24_RS19285	3882590..3883057	-	468	WP_000828177.1	sugar tyrosine-protein kinase	-
L1L24_RS19290	3883874..3884293	-	420	WP_130549555.1	hypothetical protein	-
-	3884344..3884722	-	379	-	-	Antitoxin
L1L24_RS19295	3884501..3884758	+	258	WP_000994221.1	SymE family type I addiction module toxin	Toxin
L1L24_RS19300	3884825..3885256	-	432	WP_023135248.1	hypothetical protein	-
L1L24_RS19305	3885328..3885744	-	417	WP_001748027.1	DUF2195 family protein	-
L1L24_RS19310	3885741..3886109	-	369	Protein_3789	hypothetical protein	-
L1L24_RS19315	3886108..3886173	+	66	Protein_3790	hypothetical protein	-
L1L24_RS19320	3886423..3886608	-	186	Protein_3791	transposase	-
L1L24_RS19325	3886708..3887379	-	672	WP_000058649.1	ankyrin repeat domain-containing protein	-
L1L24_RS19330	3887395..3887880	-	486	WP_000103455.1	hypothetical protein	-
L1L24_RS19335	3888222..3888458	+	237	WP_130549554.1	hypothetical protein	-
L1L24_RS19340	3888540..3888716	+	177	Protein_3795	hypothetical protein	-
L1L24_RS19345	3889184..3889546	-	363	WP_001748026.1	Arm DNA-binding domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3871769..3889546	17777

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9356.66 Da
• Isoelectric Point: 5.6373

>T232156 WP_000994221.1 NZ_CP090929:3884501-3884758 [Salmonella enterica subsp. enterica serovar Agona]
MNASGVSVRHINSETCITTCYSQIPSQHLKGDWQEEAGFETGRSVTVKISQGCIVLMADGNEVQKLCEQLYQAERVVKGL
KDVLV

Nucleotide

• Length: 258 bp

>T232156 NZ_CP127273:1764287-1764691 [Mycobacterium tuberculosis]
ATGATCCTCATCGACACATCGGCCTGGGTGGAGTACTTCCGTGCCACCGGATCAATCGCCGCTGTCGAAGTACGCCGGCT
GCTGTCCGAAGAAGCAGCGCGAATCGCTATGTGTGAGCCCATTGCGATGGAAATCTTGAGTGGCGCGCTCGACGACAACA
CCCACACGACGCTAGAGCGGCTCGTGAATGGCTTGCCGTCGTTGAACGTTGATGACGCGATTGACTTTCGTGCTGCCGCG
GGTATCTATCGCGCCGCCCGGCGCGCCGGCGAAACGGTTCGAAGCATCAACGACTGCCTCATAGCGGCGCTCGCGATCCG
CCACGGTGCGCGTATCGTCCACCGTGACGCCGACTTTGATGTGATTGCCCGGATTACCAACCTGCAGGCCGCATCGTTTC
GGTGA

Antitoxin

Nucleotide

• Length: 379 bp

>AT232156 NZ_CP090929:c3884722-3884344 [Salmonella enterica subsp. enterica serovar Agona]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCCTGTGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAG
TAACAGGTGGTTATACAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAA
TTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGCGCC
CCCCTCTCCCCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3L1ZDZ2

Antitoxin