Detailed information of TA system TA230131

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3498362..3498754
• Replicon: chromosome
• Accession: NZ_CP090141
• Organism: Salmonella enterica subsp. enterica serovar Goldcoast strain 5ASAL09

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V9S8T1
• Locus tag: LZK30_RS16885
• Protein ID: WP_000994223.1
• Coordinates: 3498509..3498754 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3498362..3498718 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZK30_RS16855	3493614..3494111	-	498	WP_165963407.1	pilus assembly protein	-
LZK30_RS16860	3494873..3495577	-	705	Protein_3299	integrase core domain-containing protein	-
LZK30_RS16865	3495630..3495944	+	315	WP_133322996.1	SymE family type I addiction module toxin	-
LZK30_RS16870	3496011..3496289	-	279	WP_133323248.1	hypothetical protein	-
LZK30_RS16875	3496607..3497074	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
LZK30_RS16880	3497892..3498311	-	420	WP_131040133.1	hypothetical protein	-
-	3498362..3498718	-	357	-	-	Antitoxin
LZK30_RS16885	3498509..3498754	+	246	WP_000994223.1	hypothetical protein	Toxin
LZK30_RS16890	3498821..3499363	-	543	WP_079984650.1	hypothetical protein	-
LZK30_RS16895	3499363..3503469	-	4107	WP_133322998.1	RHS repeat-associated core domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3485709..3499363	13654

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8789.96 Da
• Isoelectric Point: 4.1428

>T230131 WP_000994223.1 NZ_CP090141:3498509-3498754 [Salmonella enterica subsp. enterica serovar Goldcoast]
MNASGVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

>T230131 NZ_CP124732:c2283731-2283549 [Pseudomonas sp. GM17]
GTGAACAGTCGGTATTTGATCGGCCAAATCGTCGCAGACGGTTGGTATCTGGTCAGGGTCAGAGGCAGTCACCATCATTT
CAGGCATCCCAGTAAACCGGGGCTGGTGACAGTGCCACATCCCAAAAAGGACCTGCTGAGAAAAACCGCCATCAGCATTC
TGAAACAGGCGCTGCTCATGTGA

Antitoxin

Nucleotide

• Length: 357 bp

>AT230131 NZ_CP090141:c3498718-3498362 [Salmonella enterica subsp. enterica serovar Goldcoast]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V9S8T1

Antitoxin