Detailed information of TA system TA230111

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 3498253..3498645
• Replicon: chromosome
• Accession: NZ_CP090137
• Organism: Salmonella enterica subsp. enterica serovar Goldcoast strain 5ASAL05

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V9S8T1
• Locus tag: LZK31_RS16885
• Protein ID: WP_000994223.1
• Coordinates: 3498400..3498645 (+)
• Length: 82 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3498253..3498609 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LZK31_RS16855	3493505..3494002	-	498	WP_165963407.1	pilus assembly protein	-
LZK31_RS16860	3494764..3495468	-	705	Protein_3299	integrase core domain-containing protein	-
LZK31_RS16865	3495521..3495835	+	315	WP_133322996.1	SymE family type I addiction module toxin	-
LZK31_RS16870	3495902..3496180	-	279	WP_133323248.1	hypothetical protein	-
LZK31_RS16875	3496498..3496965	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
LZK31_RS16880	3497783..3498202	-	420	WP_131040133.1	hypothetical protein	-
-	3498253..3498609	-	357	-	-	Antitoxin
LZK31_RS16885	3498400..3498645	+	246	WP_000994223.1	hypothetical protein	Toxin
LZK31_RS16890	3498712..3499254	-	543	WP_079984650.1	hypothetical protein	-
LZK31_RS16895	3499254..3503360	-	4107	WP_133322998.1	RHS repeat-associated core domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3485600..3499254	13654

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 82 a.a.
• Molecular weight: 8789.96 Da
• Isoelectric Point: 4.1428

>T230111 WP_000994223.1 NZ_CP090137:3498400-3498645 [Salmonella enterica subsp. enterica serovar Goldcoast]
MNASGVSVRHINSETCMTACYSQIPSGDCQEEAGFETGRSVTVKISDGCIVLMADGNEVQKLCEQLYQAEQVVKGMWDVI
V

Nucleotide

• Length: 246 bp

>T230111 NZ_CP124702:331896-332264 [Klebsiella pneumoniae]
ATGACGCTGCAGATTATCTCAGCGGAAGAGATAATACAGTTTCACGACAGGCTGCTCCGCGTCACGCCTGGCGTTGCCGG
TATGCCCGATCCGGGGCGTGCCGAAGCGATAATGTATAGGGTGCTAAACAAAATTGAATATGAAGGTGTGACAGACGTGT
GGCGACTCGCTGCGATGCATCTGCTGGCGATTTCTCGCGGTCATATATTTAATGATGGTAATAAGCGTACGGCACTGTTT
ATCACCCTGCTTTTTTTAAAGCGAAATGGAATTATATTGCCAGCGAATCCAGACTTCGTCGGTATTACCGTCGAGGCAGC
AGCAGGGCAACTTACCCTGGAACAGATTGTCGCGCGTTTGCGTGGATGA

Antitoxin

Nucleotide

• Length: 357 bp

>AT230111 NZ_CP090137:c3498609-3498253 [Salmonella enterica subsp. enterica serovar Goldcoast]
TTCAGCCTGATAAAGCTGTTCGCACAGCTTCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCT
TCACCGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGCGGTC
ATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTC
CGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCATCGCGCCTCTCTCTCCCCG
GCCAGTGATGAGCAACCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V9S8T1

Antitoxin