Detailed information of TA system
Overview
TA module
| Type | I | Classification (family/domain) | CD-RCd/- |
| Location | 3295110..3295325 | Replicon | chromosome |
| Accession | NZ_CP090060 | ||
| Organism | Clostridioides difficile strain CDB | ||
Toxin (Protein)
| Gene name | CD2889 | Uniprot ID | Q183X5 |
| Locus tag | LWC40_RS15125 | Protein ID | WP_011861731.1 |
| Coordinates | 3295182..3295325 (-) | Length | 48 a.a. |
Antitoxin (RNA)
| Gene name | RCd12 | ||
| Locus tag | - | ||
| Coordinates | 3295110..3295256 (+) |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LWC40_RS15110 (3290769) | 3290769..3291923 | + | 1155 | WP_003439713.1 | GGDEF domain-containing protein | - |
| LWC40_RS15115 (3292004) | 3292004..3293722 | - | 1719 | WP_011861730.1 | putative 2-aminoethylphosphonate ABC transporter permease subunit | - |
| LWC40_RS15120 (3293727) | 3293727..3294593 | - | 867 | Protein_2908 | ATP-binding cassette domain-containing protein | - |
| - (3295110) | 3295110..3295256 | + | 147 | NuclAT_0 | - | Antitoxin |
| - (3295110) | 3295110..3295256 | + | 147 | NuclAT_0 | - | Antitoxin |
| - (3295110) | 3295110..3295256 | + | 147 | NuclAT_0 | - | Antitoxin |
| - (3295110) | 3295110..3295260 | + | 151 | NuclAT_1 | - | - |
| LWC40_RS15125 (3295182) | 3295182..3295325 | - | 144 | WP_011861731.1 | hypothetical protein | Toxin |
| LWC40_RS15130 (3295583) | 3295583..3295771 | + | 189 | WP_009898401.1 | hypothetical protein | - |
| LWC40_RS15135 (3296018) | 3296018..3296722 | - | 705 | WP_011861732.1 | hypothetical protein | - |
| LWC40_RS15140 (3296724) | 3296724..3297155 | - | 432 | WP_011861052.1 | protein-export chaperone SecB | - |
| LWC40_RS15145 (3297173) | 3297173..3297736 | - | 564 | WP_021371073.1 | hypothetical protein | - |
| LWC40_RS15150 (3298282) | 3298282..3298578 | - | 297 | WP_011861049.1 | hypothetical protein | - |
| LWC40_RS15155 (3298595) | 3298595..3299410 | - | 816 | WP_021362018.1 | N-acetylmuramoyl-L-alanine amidase | - |
| LWC40_RS15160 (3299407) | 3299407..3299667 | - | 261 | WP_011861047.1 | phage holin family protein | - |
| LWC40_RS15165 (3299686) | 3299686..3299916 | - | 231 | WP_021362019.1 | hemolysin XhlA family protein | - |
| LWC40_RS15170 (3299955) | 3299955..3300125 | - | 171 | WP_021362020.1 | hypothetical protein | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 48 a.a. Molecular weight: 5399.34 Da Isoelectric Point: 10.8277
>T229956 WP_011861731.1 NZ_CP090060:c3295325-3295182 [Clostridioides difficile]
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNKKRH
MSEFLLGVLASLTASFITYIISRKVKSHSGRSDFELDVKIKFNKKRH
Download Length: 144 bp
>T229956 NZ_CP124649:c5722900-5722718 [Pseudomonas aeruginosa]
ATGCGGAGTAGGGAAGTGATTGATTTGCTGTTGGAGGATGGCTGGTATGAAGTGGCGGTGAAAGGTAGCCACCACCAGTT
CAAACATCCTTCAAAGCCTGGAAAGGTGACGGTTCAACATCCGTCCTCGACGATACCGAAAGGAACCCTGAACAACATAC
TGAAACAAGCCGGCCTCAAGTGA
ATGCGGAGTAGGGAAGTGATTGATTTGCTGTTGGAGGATGGCTGGTATGAAGTGGCGGTGAAAGGTAGCCACCACCAGTT
CAAACATCCTTCAAAGCCTGGAAAGGTGACGGTTCAACATCCGTCCTCGACGATACCGAAAGGAACCCTGAACAACATAC
TGAAACAAGCCGGCCTCAAGTGA
Antitoxin
Download Length: 147 bp
>AT229956 NZ_CP090060:3295110-3295256 [Clostridioides difficile]
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTC
GTTTTTTATTAAACTTGATTTTTACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTT
GTAAATTCGTATCAAAAACAAAAAAAGAAACTACAATCTATTAGCCTAGAGTGAAGTTTCATTAACTAAATATTAATGTC
GTTTTTTATTAAACTTGATTTTTACATCAAGCTCAAAGTCACTCCTGCCAGAGTGGCTTTTTACTTT
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
