Detailed information of TA system TA229947

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 1534282..1534478
• Replicon: chromosome
• Accession: NZ_CP090060
• Organism: Clostridioides difficile strain CDB

Toxin (Protein)

• Gene name: CD1418.2
• Uniprot ID: Q18BT8
• Locus tag: LWC40_RS07225
• Protein ID: WP_009902496.1
• Coordinates: 1534282..1534434 (+)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	CD630_n00500
Locus tag	-
Coordinates	1534378..1534478 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LWC40_RS07205 (1529822)	1529822..1530370	-	549	WP_011861206.1	DUF308 domain-containing protein	-
LWC40_RS07210 (1530522)	1530522..1530950	+	429	WP_011861207.1	DMT family transporter	-
LWC40_RS07215 (1531017)	1531017..1531685	+	669	WP_003429358.1	diphthine--ammonia ligase	-
LWC40_RS07220 (1531803)	1531803..1533158	-	1356	WP_003438549.1	MATE family efflux transporter	-
LWC40_RS07225 (1534282)	1534282..1534434	+	153	WP_009902496.1	hypothetical protein	Toxin
- (1534378)	1534378..1534478	-	101	NuclAT_3	-	Antitoxin
- (1534378)	1534378..1534478	-	101	NuclAT_3	-	Antitoxin
- (1534378)	1534378..1534478	-	101	NuclAT_4	-	Antitoxin
LWC40_RS07230 (1535864)	1535864..1537597	-	1734	WP_009902497.1	sensor domain-containing diguanylate cyclase	-
LWC40_RS07235 (1537837)	1537837..1538682	-	846	WP_009889222.1	c-di-GMP diguanylate cyclase DccA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5742.81 Da
• Isoelectric Point: 10.9178

>T229947 WP_009902496.1 NZ_CP090060:1534282-1534434 [Clostridioides difficile]
MDNFLQGVLASLVASLIVYLNSKLFKKVKSHSGRSDFSFELKIKFKKNKH

Nucleotide

• Length: 153 bp

>T229947 NZ_CP124648:c2667508-2667227 [Pseudomonas aeruginosa]
ATGAGCCTGAAGTGGACCCGCAAGGCGGCCGCCGACCTGGACGCCATCTACGACCATTACGTCGTGCTGATCGGCCCGGA
AAAAGCCCTGAAAGCCGTCCAGGACATCGTCGAGCAGGTGAAACCGCTGCAGCAGGTGGCCAACCAGGGGGCAGGGCGGC
CCAGCGAGGTGCCAGGCGTACGCACCCTGAACCTGGAGCGCTGGCCGTTCAGCGCCCCTTTTCGGGTAAAAGGCAAGGAA
ATCCAGATTTTGCGCATCGACAGGGTCGAAATTACCCCCTGA

Antitoxin

Nucleotide

• Length: 101 bp

>AT229947 NZ_CP090060:c1534478-1534378 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTTTAGTTC
AAAACTAAAGTCACTCCTGCC

Structures

Toxin

• AlphaFold DB: A0A069ACY9

Antitoxin