Detailed information of TA system TA229468

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3618255..3618669
• Replicon: chromosome
• Accession: NZ_CP089799
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00785

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V3U6I8
• Locus tag: LUY21_RS17695
• Protein ID: WP_023203422.1
• Coordinates: 3618412..3618669 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3618255..3618587 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUY21_RS17665	3613512..3614009	-	498	WP_058654878.1	Saf-pilin pilus formation protein SafA	-
LUY21_RS17670	3614770..3615474	-	705	Protein_3458	integrase core domain-containing protein	-
LUY21_RS17675	3615527..3615763	+	237	Protein_3459	SymE family type I addiction module toxin	-
LUY21_RS17680	3615908..3616186	-	279	WP_012664366.1	hypothetical protein	-
LUY21_RS17685	3616504..3616971	-	468	WP_000828182.1	sugar tyrosine-protein kinase	-
LUY21_RS17690	3617064..3617339	-	276	WP_223163371.1	hypothetical protein	-
-	3618255..3618587	-	333	-	-	Antitoxin
LUY21_RS17695	3618412..3618669	+	258	WP_023203422.1	SymE family type I addiction module toxin	Toxin
LUY21_RS17700	3618728..3619036	-	309	WP_023203423.1	hypothetical protein	-
LUY21_RS17705	3619055..3619462	-	408	WP_024146273.1	DUF4329 domain-containing protein	-
LUY21_RS17710	3619823..3620344	-	522	WP_023203424.1	SMI1/KNR4 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3596279..3652246	55967
	-	flank	IS/Tn	-	-	3614770..3615051	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.71 Da
• Isoelectric Point: 7.2431

>T229468 WP_023203422.1 NZ_CP089799:3618412-3618669 [Salmonella enterica subsp. enterica serovar Kentucky]
MNASGASVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T229468 NZ_CP124481:960225-960512 [Escherichia coli]
ATGCCAATGGAGTTTGAATGGGATGAAAACAAGGCCAAAAGTAATCGGGTGAAACATGGCATCCGCTTTGAAGATGCGGT
GTTATTGTTTGATGATCCACAACATTTGTCACAGCAAGAACGCATAGAAAACGGTGAGTATCGCTGGCAGACAATCGGCC
TGGTTTACGGCATCGTGGTTATTCTGGTTGCGCATACCATCCGTTTCGAAAGCGGAAATGAAATTATTCGAATCATCAGT
GCACGAAAAGCAGATCGTAAAGAGAGGAATCGCTATGAGCATGGTTAA

Antitoxin

Nucleotide

• Length: 333 bp

>AT229468 NZ_CP089799:c3618587-3618255 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V3U6I8

Antitoxin