Detailed information of TA system TA229447

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3618889..3619303
• Replicon: chromosome
• Accession: NZ_CP089798
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00789

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V3U6I8
• Locus tag: LUY14_RS17690
• Protein ID: WP_023203422.1
• Coordinates: 3619046..3619303 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3618889..3619221 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUY14_RS17660	3614146..3614643	-	498	WP_058654878.1	Saf-pilin pilus formation protein SafA	-
LUY14_RS17665	3615404..3616108	-	705	Protein_3457	integrase core domain-containing protein	-
LUY14_RS17670	3616161..3616397	+	237	Protein_3458	SymE family type I addiction module toxin	-
LUY14_RS17675	3616542..3616820	-	279	WP_012664366.1	hypothetical protein	-
LUY14_RS17680	3617138..3617605	-	468	WP_000828182.1	sugar tyrosine-protein kinase	-
LUY14_RS17685	3617698..3617973	-	276	WP_223163371.1	hypothetical protein	-
-	3618889..3619221	-	333	-	-	Antitoxin
LUY14_RS17690	3619046..3619303	+	258	WP_023203422.1	SymE family type I addiction module toxin	Toxin
LUY14_RS17695	3619362..3619670	-	309	WP_023203423.1	hypothetical protein	-
LUY14_RS17700	3619689..3620096	-	408	WP_024146273.1	DUF4329 domain-containing protein	-
LUY14_RS17705	3620457..3620978	-	522	WP_023203424.1	SMI1/KNR4 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3598595..3652880	54285
	-	flank	IS/Tn	-	-	3615404..3615685	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.71 Da
• Isoelectric Point: 7.2431

>T229447 WP_023203422.1 NZ_CP089798:3619046-3619303 [Salmonella enterica subsp. enterica serovar Kentucky]
MNASGASVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T229447 NZ_CP124475:1899903-1900157 [Escherichia coli]
GTGAAACTAATCTGGTCTGAGGAATCATGGGATGATTATCTGTACTGGCAGGAAACAGATAAGCGAATTGTTAAAAAGAT
CAATGAAATTATCAAAGATACACGCAGAACACCATTTGAAGGTAAGGGGAAGCCAGAACCCCTGAAACATAATTTGTCAG
GCTTCTGGTCCCGACGCATTACAGAGGAGCACCGTCTGGTATACGCGGTTACCGACGATTCACTGCTCATTGCAGCATGT
CGTTATCATTATTGA

Antitoxin

Nucleotide

• Length: 333 bp

>AT229447 NZ_CP089798:c3619221-3618889 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V3U6I8

Antitoxin