Detailed information of TA system TA229384

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3618242..3618656
• Replicon: chromosome
• Accession: NZ_CP089794
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00814

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V3U6I8
• Locus tag: LUY18_RS17675
• Protein ID: WP_023203422.1
• Coordinates: 3618399..3618656 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3618242..3618574 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUY18_RS17645	3613499..3613996	-	498	WP_058654878.1	Saf-pilin pilus formation protein SafA	-
LUY18_RS17650	3614757..3615461	-	705	Protein_3456	integrase core domain-containing protein	-
LUY18_RS17655	3615514..3615750	+	237	Protein_3457	SymE family type I addiction module toxin	-
LUY18_RS17660	3615895..3616173	-	279	WP_012664366.1	hypothetical protein	-
LUY18_RS17665	3616491..3616958	-	468	WP_000828182.1	sugar tyrosine-protein kinase	-
LUY18_RS17670	3617051..3617326	-	276	WP_223163371.1	hypothetical protein	-
-	3618242..3618574	-	333	-	-	Antitoxin
LUY18_RS17675	3618399..3618656	+	258	WP_023203422.1	SymE family type I addiction module toxin	Toxin
LUY18_RS17680	3618715..3619023	-	309	WP_023203423.1	hypothetical protein	-
LUY18_RS17685	3619042..3619449	-	408	WP_024146273.1	DUF4329 domain-containing protein	-
LUY18_RS17690	3619810..3620331	-	522	WP_023203424.1	SMI1/KNR4 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3596267..3652233	55966
	-	flank	IS/Tn	-	-	3614757..3615038	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.71 Da
• Isoelectric Point: 7.2431

>T229384 WP_023203422.1 NZ_CP089794:3618399-3618656 [Salmonella enterica subsp. enterica serovar Kentucky]
MNASGASVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T229384 NZ_CP124460:3573063-3573347 [Escherichia coli]
ATGCAATTTACGGTATACCGCAGTCGCGGCAGGAACGCCGCGTTTCCCTTTGTTATTGATGTTACCAGCGACATTATTGG
TGAGATTAATCGCCGTATCGTTATTCCATTAACACCTATTGAACGATTTAGCCGTATTCGCCCACCAGAACGGCTTAACC
CAATCCTTTTACTGATAGACGGCAAAGAATATGTGCTCATGACGCATGAGACTGCAACTGTTCCAGTTAACGCGCTGGGA
ACGAAATTTTGCGATGCCAGCGCGCACCGAACGTTGATTAAATGA

Antitoxin

Nucleotide

• Length: 333 bp

>AT229384 NZ_CP089794:c3618574-3618242 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V3U6I8

Antitoxin