Detailed information of TA system TA229363

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3615756..3616170
• Replicon: chromosome
• Accession: NZ_CP089792
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00816

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V3U6I8
• Locus tag: LUY16_RS17670
• Protein ID: WP_023203422.1
• Coordinates: 3615913..3616170 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3615756..3616088 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUY16_RS17640	3611013..3611510	-	498	WP_058654878.1	Saf-pilin pilus formation protein SafA	-
LUY16_RS17645	3612271..3612975	-	705	Protein_3456	integrase core domain-containing protein	-
LUY16_RS17650	3613028..3613264	+	237	Protein_3457	SymE family type I addiction module toxin	-
LUY16_RS17655	3613409..3613687	-	279	WP_012664366.1	hypothetical protein	-
LUY16_RS17660	3614005..3614472	-	468	WP_000828182.1	sugar tyrosine-protein kinase	-
LUY16_RS17665	3614565..3614840	-	276	WP_223163371.1	hypothetical protein	-
-	3615756..3616088	-	333	-	-	Antitoxin
LUY16_RS17670	3615913..3616170	+	258	WP_023203422.1	SymE family type I addiction module toxin	Toxin
LUY16_RS17675	3616229..3616537	-	309	WP_023203423.1	hypothetical protein	-
LUY16_RS17680	3616556..3616963	-	408	WP_024146273.1	DUF4329 domain-containing protein	-
LUY16_RS17685	3617324..3617845	-	522	WP_023203424.1	SMI1/KNR4 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3593781..3649748	55967
	-	flank	IS/Tn	-	-	3612271..3612552	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.71 Da
• Isoelectric Point: 7.2431

>T229363 WP_023203422.1 NZ_CP089792:3615913-3616170 [Salmonella enterica subsp. enterica serovar Kentucky]
MNASGASVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T229363 NZ_CP124455:c4686188-4686081 [Escherichia coli]
ATGACGCTCGCAGAGCTGGGCATGGCCTTCTGGCATGATTTAGCGGCTCCGGTCATTGCTGGCATTCTTGCCAGTATGAT
CGTGAACTGGCTGAACAAGCGGAAGTAA

Antitoxin

Nucleotide

• Length: 333 bp

>AT229363 NZ_CP089792:c3616088-3615756 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V3U6I8

Antitoxin