Detailed information of TA system TA229321

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3617754..3618168
• Replicon: chromosome
• Accession: NZ_CP089790
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00830

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V3U6I8
• Locus tag: LUY12_RS17670
• Protein ID: WP_023203422.1
• Coordinates: 3617911..3618168 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3617754..3618086 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUY12_RS17640	3613011..3613508	-	498	WP_058654878.1	Saf-pilin pilus formation protein SafA	-
LUY12_RS17645	3614269..3614973	-	705	Protein_3456	integrase core domain-containing protein	-
LUY12_RS17650	3615026..3615262	+	237	Protein_3457	SymE family type I addiction module toxin	-
LUY12_RS17655	3615407..3615685	-	279	WP_012664366.1	hypothetical protein	-
LUY12_RS17660	3616003..3616470	-	468	WP_000828182.1	sugar tyrosine-protein kinase	-
LUY12_RS17665	3616563..3616838	-	276	WP_223163371.1	hypothetical protein	-
-	3617754..3618086	-	333	-	-	Antitoxin
LUY12_RS17670	3617911..3618168	+	258	WP_023203422.1	SymE family type I addiction module toxin	Toxin
LUY12_RS17675	3618227..3618535	-	309	WP_023203423.1	hypothetical protein	-
LUY12_RS17680	3618554..3618961	-	408	WP_024146273.1	DUF4329 domain-containing protein	-
LUY12_RS17685	3619322..3619843	-	522	WP_023203424.1	SMI1/KNR4 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3595781..3651745	55964
	-	flank	IS/Tn	-	-	3614269..3614550	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.71 Da
• Isoelectric Point: 7.2431

>T229321 WP_023203422.1 NZ_CP089790:3617911-3618168 [Salmonella enterica subsp. enterica serovar Kentucky]
MNASGASVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T229321 NZ_CP124442:868128-868502 [Escherichia coli]
ATGAAAACATTACCTGTATTACCCGGGCAGGCGGCCAGTTCTCGCCCGTCTCCTGTTGAAATCTGGCAGATACTGCTGTC
CCGACTGCTGGACCAGCACTATGGCCTCACACTGAATGACACACCGTTTGCCGATGAACGTGTGATTGAGCAGCATATTG
AGGCAGGCATTTCACTGTGTGATGCGGTGAACTTTCTCGTGGAAAAATACGCGCTGGTGCGTACCGACCAGCCGGGATTC
AGCGCCTGTACCCGCTCTCAGTTAATAAACAGCATCGATATCCTCCGGGCTCGCAGGGCGACCGGCCTGATGACCAGCGA
CAATTACAGAACGGTAAATAACATTACCCTGGGTAAGTATCCGGAGGCGAAATGA

Antitoxin

Nucleotide

• Length: 333 bp

>AT229321 NZ_CP089790:c3618086-3617754 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V3U6I8

Antitoxin