Detailed information of TA system TA229269

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 1267310..1267724
• Replicon: chromosome
• Accession: NZ_CP089788
• Organism: Salmonella enterica subsp. enterica serovar Kentucky strain ZTA19/00847

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V3U6I8
• Locus tag: LUY19_RS05915
• Protein ID: WP_023203422.1
• Coordinates: 1267310..1267567 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	1267392..1267724 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LUY19_RS05900	1265635..1266156	+	522	WP_023203424.1	SMI1/KNR4 family protein	-
LUY19_RS05905	1266517..1266924	+	408	WP_024146273.1	DUF4329 domain-containing protein	-
LUY19_RS05910	1266943..1267251	+	309	WP_023203423.1	hypothetical protein	-
LUY19_RS05915	1267310..1267567	-	258	WP_023203422.1	SymE family type I addiction module toxin	Toxin
-	1267392..1267724	+	333	-	-	Antitoxin
LUY19_RS05920	1268640..1268915	+	276	WP_223163371.1	hypothetical protein	-
LUY19_RS05925	1269008..1269475	+	468	WP_000828182.1	sugar tyrosine-protein kinase	-
LUY19_RS05930	1269793..1270071	+	279	WP_012664366.1	hypothetical protein	-
LUY19_RS05935	1270216..1270452	-	237	Protein_1142	SymE family type I addiction module toxin	-
LUY19_RS05940	1270505..1271209	+	705	Protein_1143	integrase core domain-containing protein	-
LUY19_RS05945	1271970..1272467	+	498	WP_058654878.1	Saf-pilin pilus formation protein SafA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	1235222..1290438	55216
	-	flank	IS/Tn	-	-	1270928..1271209	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.71 Da
• Isoelectric Point: 7.2431

>T229269 WP_023203422.1 NZ_CP089788:c1267567-1267310 [Salmonella enterica subsp. enterica serovar Kentucky]
MNASGASVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T229269 NZ_CP124429:434981-435331 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACGCGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 333 bp

>AT229269 NZ_CP089788:1267392-1267724 [Salmonella enterica subsp. enterica serovar Kentucky]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V3U6I8

Antitoxin