Detailed information of TA system TA228039

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3629569..3629820
• Replicon: chromosome
• Accession: NZ_CP089313
• Organism: Salmonella enterica subsp. enterica serovar Indiana strain YZ21MCS4

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: LT987_RS17840
• Protein ID: WP_131166435.1
• Coordinates: 3629569..3629820 (+)
• Length: 84 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3629585..3629810 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LT987_RS17820	3626097..3626837	-	741	WP_051129375.1	pili assembly chaperone SafB	-
LT987_RS17825	3626912..3627409	-	498	WP_051129374.1	Saf-pilin pilus formation protein SafA	-
LT987_RS17830	3627542..3628036	-	495	WP_051129373.1	hypothetical protein	-
LT987_RS17835	3628804..3629505	-	702	Protein_3496	integrase core domain-containing protein	-
LT987_RS17840	3629569..3629820	+	252	WP_131166435.1	SymE family type I addiction module toxin	Toxin
-	3629585..3629810	-	226	-	-	Antitoxin
LT987_RS17845	3629866..3630330	-	465	WP_127201574.1	hypothetical protein	-
LT987_RS17850	3630711..3631556	-	846	Protein_3499	RHS domain-containing protein	-
LT987_RS17855	3631576..3631713	+	138	WP_023227287.1	hypothetical protein	-
LT987_RS17860	3631856..3632464	-	609	WP_053505599.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3609701..3654015	44314
	-	flank	IS/Tn	-	-	3628804..3629082	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (10-48)

Sequences

Toxin

Protein

• Length: 84 a.a.
• Molecular weight: 9451.82 Da
• Isoelectric Point: 8.0365

>T228039 WP_131166435.1 NZ_CP089313:3629569-3629820 [Salmonella enterica subsp. enterica serovar Indiana]
MRDTYKTHMTTYYSRIPSLHLKGDWLAEAGFDTGASVTVKISEGCLTLIVETDEVRDLRRELYQVKKSMKHIKAGVYDVV
NGN

Nucleotide

• Length: 252 bp

>T228039 NZ_CP123260:2756028-2756135 [Escherichia coli]
ATGACGCTCGCGCAGTTTGCCATGACTTTCTGGCACGACCTGGCAGCACCGATCCTGGCGGGGATTATTACCGCAGCGAT
TGTCAGCTGGTGGCGTAACCGGAAGTAA

Antitoxin

Nucleotide

• Length: 226 bp

>AT228039 NZ_CP089313:c3629810-3629585 [Salmonella enterica subsp. enterica serovar Indiana]
TTCACCACATCATATACCCCCGCCTTAATGTGCTTCATCGACTTTTTCACCTGATAAAGCTCCCTCCGTAGATCCCTCAC
TTCGTCTGTCTCCACAATCAGAGTCAAACACCCTTCGGAGATCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCGCCCTTAAGGTGCAGGCTGGGGATGCGCGAGTAATAGGTGGTCATGTGGGTTT

Structures

Antitoxin