Detailed information of TA system TA226781

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/-
• Location: 4259705..4260107
• Replicon: chromosome
• Accession: NZ_CP088136
• Organism: Salmonella enterica subsp. enterica serovar Typhimurium strain SCPM-O-B-4515

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: LRM91_RS23075
• Protein ID: WP_023209683.1
• Coordinates: 4259979..4260107 (+)
• Length: 43 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	4259705..4260057 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRM91_RS20505	4255106..4255603	-	498	WP_249895254.1	Saf-pilin pilus formation protein SafA	-
LRM91_RS20510	4256225..4256929	-	705	Protein_4027	integrase core domain-containing protein	-
LRM91_RS20515	4256982..4257230	+	249	WP_001746936.1	SymE family type I addiction module toxin	-
LRM91_RS20520	4257362..4257640	-	279	WP_077677834.1	hypothetical protein	-
LRM91_RS20525	4258026..4258424	-	399	WP_000828181.1	hypothetical protein	-
LRM91_RS20530	4259295..4259528	-	234	WP_124084119.1	hypothetical protein	-
-	4259705..4260057	-	353	-	-	Antitoxin
LRM91_RS23075	4259979..4260107	+	129	WP_023209683.1	hypothetical protein	Toxin
LRM91_RS20535	4260190..4260459	-	270	WP_249895255.1	Imm8 family immunity protein	-
LRM91_RS20540	4261290..4261655	-	366	WP_249895256.1	hypothetical protein	-
LRM91_RS20545	4261621..4264421	-	2801	Protein_4035	RHS repeat-associated core domain-containing protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4250036..4284237	34201
	-	flank	IS/Tn	-	-	4256225..4256506	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 43 a.a.
• Molecular weight: 4492.16 Da
• Isoelectric Point: 4.4551

>T226781 WP_023209683.1 NZ_CP088136:4259979-4260107 [Salmonella enterica subsp. enterica serovar Typhimurium]
VKISDGCIVLMADGNEVQELREQLYQAKRVVKGGEGCAGLVD

Nucleotide

• Length: 129 bp

>T226781 NZ_CP122625:c2448324-2448148 [Escherichia coli]
GTGAAACAAAGCGAGTTCAGACGTTGGCTCGAATCTCAGGGCGTCGATGTAGCGAATAGCAGCAACCATTTGAAACTCAG
GTTTCATGGGAGGCGCAGTGTCATGCCGCGTCACCCCTGCGATGAGATTAAAGAACCATTGCGTAAAGCAATCCTGAAAC
AACTCGGTTTGAGTTAA

Antitoxin

Nucleotide

• Length: 353 bp

>AT226781 NZ_CP088136:c4260057-4259705 [Salmonella enterica subsp. enterica serovar Typhimurium]
CCTGATAAAGCTGTTCGCGCAGCTCCTGCACCTCGTTACCGTCCGCCATTAGCACAATACACCCGTCCGAAATCTTCACC
GTCACGCCGCTCCCCGGTCTCAAATCCCGCTTCTTCCTGGCAGTCGCCGCTGGGGATTTGTGAGTAACAGGTGGTCATGC
AGGTTTCGCTGTTGATGTGGCGGACGCTGGCGCCGGAGGTATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCC
GGATGCTGGCTGATTGTGGAGCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCCCCCTCTCCCCGGCCA
GTGATGAGCAACCGGCTACCGGGGCCGTATTTT

Structures

Antitoxin