Detailed information of TA system TA226742

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 1011875..1012279
• Replicon: chromosome
• Accession: NZ_CP088134
• Organism: Salmonella enterica subsp. enterica serovar Gallinarum strain SCPM-O-B-4493

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: Q57SW9
• Locus tag: LRM90_RS05145
• Protein ID: WP_000994220.1
• Coordinates: 1012022..1012279 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	1011875..1012197 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LRM90_RS05115	1007122..1007634	-	513	WP_001539124.1	Saf-pilin pilus formation protein SafA	-
LRM90_RS05120	1008384..1009088	-	705	Protein_1000	integrase core domain-containing protein	-
LRM90_RS05125	1009141..1009455	+	315	WP_001539118.1	SymE family type I addiction module toxin	-
LRM90_RS05130	1009522..1009800	-	279	WP_012664366.1	hypothetical protein	-
LRM90_RS05135	1010118..1010585	-	468	WP_001539113.1	sugar tyrosine-protein kinase	-
LRM90_RS05140	1010678..1010902	-	225	WP_001538166.1	hypothetical protein	-
-	1011875..1012197	-	323	-	-	Antitoxin
LRM90_RS05145	1012022..1012279	+	258	WP_000994220.1	SymE family type I addiction module toxin	Toxin
LRM90_RS05150	1012338..1012646	-	309	WP_001539109.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	flank	IS/Tn	-	-	1008384..1008665	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9426.84 Da
• Isoelectric Point: 7.1053

>T226742 WP_000994220.1 NZ_CP088134:1012022-1012279 [Salmonella enterica subsp. enterica serovar Gallinarum]
MNASGVSVRHINSETCITTCYSQIPSLHLKGDWLEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T226742 NZ_CP122620:731841-732137 [Escherichia coli]
ATGGAAAAACGCACACCACATACACGTTTGAGTCAGGTTAAAAAACTTGTCAATGCCGGGCAAGTTCGTACAACACGTAG
TGCCCTGTTAAATGCAGATGAGTTAGGTTTGGATTTTGATGGTATGTGTAATGTTATCATTGGATTATCAGAGAGCGACT
TTTATAAAAGCATGACCACCTACTCTGATCATACTATCTGGCAGGATGTTTACAGACCCAGGCTTGTTACAGGCCAGGTT
TATCTTAAAATTACGGTAATTCATGACGTACTGATCGTCTCGTTTAAGGAGAAGTAA

Antitoxin

Nucleotide

• Length: 323 bp

>AT226742 NZ_CP088134:c1012197-1011875 [Salmonella enterica subsp. enterica serovar Gallinarum]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCAGCCA
GTCGCCCTTAAGGTGCAGGCTGGGGATTTGTGAGTAACAGGTGGTTATACAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGTGAGTATGGGCGCGACATCCTGGCACTGTGCCCCCCTCTCCCCGGCCAGTGATGAGCAACCGGCTGCCGGGGCCGTAT
TTT

Structures

Toxin

• AlphaFold DB: A0A5H5BJ07

Antitoxin