225603

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) /HTH_19(antitoxin)
Location 323278..324069 Replicon chromosome
Accession NZ_CP087593
Organism Staphylococcus aureus strain Newman NM-CQ

Toxin (Protein)


Gene name - Uniprot ID A0A380E6V7
Locus tag LO764_RS01435 Protein ID WP_000525007.1
Coordinates 323278..323742 (-) Length 155 a.a.

Antitoxin (Protein)


Gene name - Uniprot ID A0A0E7YIA0
Locus tag LO764_RS01440 Protein ID WP_000333630.1
Coordinates 323755..324069 (-) Length 105 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LO764_RS01415 (318814) 318814..320745 + 1932 Protein_280 YSIRK domain-containing triacylglycerol lipase Lip2/Geh -
LO764_RS01420 (320839) 320839..322044 - 1206 WP_000264186.1 tyrosine-type recombinase/integrase -
LO764_RS01425 (322155) 322155..322334 + 180 WP_000337827.1 hypothetical protein -
LO764_RS01430 (322314) 322314..323246 - 933 WP_000392183.1 hypothetical protein -
LO764_RS01435 (323278) 323278..323742 - 465 WP_000525007.1 hypothetical protein Toxin
LO764_RS01440 (323755) 323755..324069 - 315 WP_000333630.1 helix-turn-helix transcriptional regulator Antitoxin
LO764_RS01445 (324221) 324221..324457 + 237 WP_001121116.1 helix-turn-helix transcriptional regulator -
LO764_RS01450 (324471) 324471..324650 + 180 WP_000438352.1 hypothetical protein -
LO764_RS01455 (324751) 324751..325233 - 483 WP_000394410.1 hypothetical protein -
LO764_RS01460 (325293) 325293..326042 + 750 WP_001148586.1 phage antirepressor KilAC domain-containing protein -
LO764_RS01465 (326058) 326058..326156 + 99 Protein_290 hypothetical protein -
LO764_RS01470 (326306) 326306..326569 + 264 WP_001124198.1 helix-turn-helix domain-containing protein -
LO764_RS01475 (326581) 326581..326742 + 162 WP_000066021.1 DUF1270 family protein -
LO764_RS01480 (326834) 326834..327094 + 261 WP_000291089.1 DUF1108 family protein -
LO764_RS01485 (327104) 327104..327325 + 222 WP_000815401.1 DUF2483 family protein -
LO764_RS01490 (327318) 327318..328106 + 789 WP_000134097.1 ATP-binding protein -
LO764_RS01495 (328135) 328135..328686 + 552 WP_000704705.1 single-stranded DNA-binding protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - - 320839..363160 42321


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin


No domain identified.


Antitoxin

Cro/C1-type helix-turn-helix domain

(4-62)


Sequences

Toxin        


Download         Length: 155 a.a.        Molecular weight: 18100.42 Da        Isoelectric Point: 4.7904

>T225603 WP_000525007.1 NZ_CP087593:c323742-323278 [Staphylococcus aureus]
MGLYEETLIQHDYIEIREADVLPDNLDGVWLGDLILIKRGLSDREKAGILFEELAHNKLTYGDIADYSNFNNRKFENYAR
RHGFISAVPLREIVEAHNYGVRNLYELSEYLQLSEEYILEAIEQYKKIYGIGTHYGEFSITFEPLRVFKLHHID

Download         Length: 465 bp

>T225603 NZ_CP121204:2136789-2137253 [Staphylococcus aureus]
ATGGGATTATATGAAGAAACTTTAATACAACATGATTATATTGAAATAAGAGAGGCTGATGTACTTCCAGATAATTTAGA
CGGGGTATGGTTAGGAGATTTAATTTTAATAAAGCGTGGTTTATCAGATAGAGAAAAGGCAGGAATTCTCTTCGAAGAAT
TAGCACATAATAAACTTACATACGGTGATATAGCCGATTACTCGAAATTCAACAATCGCAAGTTCGAAAATTACGCAAGA
CGACACGGCTTTATCTCAGCTGTACCGCTACGCGAAATTGTGGAAGCTTATAATTATGGCGTACGCAACTTGTATGAGTT
GTCTGAGTATCTACAATTAAGCGAAGAATACATATTAGAAGCAATAGAACAATATAAAAAGATATATGGTATTGGAACTC
ACTATGGCGAGTATTCTATTACATTTGAGCCGTTGAGAGTTTTTAAATTGCATCATATTGATTAA

Antitoxin


Download         Length: 105 a.a.        Molecular weight: 12063.56 Da        Isoelectric Point: 6.4736

>AT225603 WP_000333630.1 NZ_CP087593:c324069-323755 [Staphylococcus aureus]
MCFSKRMKQSREKQGMTLAELGRKIGKTEATVQRYESGNIKNLKNDTIESIATALNVNPAYLMGWVEENDDEVQHRAAHL
EGELTDDEWQRVLDYADYIRSKRK

Download         Length: 315 bp

>AT225603 NZ_CP121204:2136447-2136776 [Staphylococcus aureus]
ATGAGAAACAATGATGAAATAATCACAATAATCAAAACATCTATGAAAGAACAGAATTTATCACTTAGTGAATTGGCTCG
TCGTGTAGGAGTTGCTAAATCTGCTGTGTCACGTTATTTAAATTTAACGAGAGAATTTCCATTAAATAGAGCAGAAGATT
TCGCAAAAGCGCTTAGTATCAGCACAGAATATTTACTTGGTTTTGAAAAAAGTGAACAAAAACAAGAAGAACCACAGCAC
CGTGCAGCTCACCTTGAAGGAGAATTGACAGATGATGAATGGCAAAGAGTTTTAGATTATGCAGATTATATAAGAAGCAA
ACGTAAGTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A380E6V7

Antitoxin

Source ID Structure
AlphaFold DB A0A0E7YIA0

References