Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 4568486..4568898 Replicon chromosome
Accession NZ_CP087136
Organism Escherichia coli strain JW5503

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag LOX89_RS22200 Protein ID WP_000132601.1
Coordinates 4568486..4568827 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 4568822..4568898 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LOX89_RS22190 (4565899) 4565899..4566945 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
LOX89_RS22195 (4566945) 4566945..4568324 - 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
LOX89_RS22200 (4568486) 4568486..4568827 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- (4568822) 4568822..4568898 + 77 NuclAT_14 - Antitoxin
- (4568822) 4568822..4568898 + 77 NuclAT_14 - Antitoxin
- (4568822) 4568822..4568898 + 77 NuclAT_14 - Antitoxin
- (4568822) 4568822..4568898 + 77 NuclAT_14 - Antitoxin
- (4568822) 4568822..4568898 + 77 NuclAT_15 - Antitoxin
- (4568822) 4568822..4568898 + 77 NuclAT_15 - Antitoxin
- (4568822) 4568822..4568898 + 77 NuclAT_15 - Antitoxin
- (4568822) 4568822..4568898 + 77 NuclAT_15 - Antitoxin
LOX89_RS22205 (4569055) 4569055..4570449 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
LOX89_RS22210 (4570446) 4570446..4572035 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4561401..4570449 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T224854 WP_000132601.1 NZ_CP087136:c4568827-4568486 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

>T224854 NZ_CP120567:1381806-1382141 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATACGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTCTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 77 bp

>AT224854 NZ_CP087136:4568822-4568898 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References