Detailed information of TA system TA222396

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3794541..3794955
• Replicon: chromosome
• Accession: NZ_CP085983
• Organism: Salmonella enterica strain SZL 31

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5I5SV33
• Locus tag: LJY15_RS18525
• Protein ID: WP_023243487.1
• Coordinates: 3794698..3794955 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3794541..3794873 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJY15_RS18495	3789794..3790357	-	564	WP_227969897.1	Saf-pilin pilus formation protein SafA	-
LJY15_RS18500	3791056..3791757	-	702	Protein_3608	integrase core domain-containing protein	-
LJY15_RS18505	3791810..3792124	+	315	WP_023892102.1	SymE family type I addiction module toxin	-
LJY15_RS18510	3792191..3792469	-	279	WP_077677834.1	hypothetical protein	-
LJY15_RS18515	3792786..3793253	-	468	WP_000828178.1	sugar tyrosine-protein kinase	-
LJY15_RS18520	3794071..3794364	-	294	WP_039515457.1	hypothetical protein	-
-	3794541..3794873	-	333	-	-	Antitoxin
LJY15_RS18525	3794698..3794955	+	258	WP_023243487.1	SymE family type I addiction module toxin	Toxin
LJY15_RS18530	3795022..3795366	-	345	WP_023218822.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3772568..3817952	45384
	-	flank	IS/Tn	-	-	3791056..3791334	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9498.73 Da
• Isoelectric Point: 6.2112

>T222396 WP_023243487.1 NZ_CP085983:3794698-3794955 [Salmonella enterica]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFETGRSVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T222396 NZ_CP117850:1365850-1366125 [Salmonella enterica subsp. enterica serovar Mbandaka]
ATGGGACAAAGGGAAATTGAATATTCGGGACAGTTCCAGAAAGATGTAAAACGGGCACAAAAGCGTCATAAGGATGTCGG
CAAACTTAAAACACTTATGACGCTTCTGATTCACCACCCTTTTCCCCTTCCTGCCATTTATAAAGATCACCCGTTACAAG
GTTCATATAGCGGATACCGGGATGCCCATATTGAGCCTGACTGGATTCTTATTTATAAGATAACGGATGAATGCCTGCGA
TTTGAACGAACAGGAACGCATGCCGATTTATTTTAA

Antitoxin

Nucleotide

• Length: 333 bp

>AT222396 NZ_CP085983:c3794873-3794541 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCTCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5I5SV33

Antitoxin