Detailed information of TA system TA222372

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 4410382..4410796
• Replicon: chromosome
• Accession: NZ_CP085981
• Organism: Salmonella enterica strain SZL 30

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5I5SV33
• Locus tag: LJY16_RS21695
• Protein ID: WP_023243487.1
• Coordinates: 4410382..4410639 (-)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	4410464..4410796 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LJY16_RS21690	4409971..4410315	+	345	WP_023218822.1	hypothetical protein	-
LJY16_RS21695	4410382..4410639	-	258	WP_023243487.1	SymE family type I addiction module toxin	Toxin
-	4410464..4410796	+	333	-	-	Antitoxin
LJY16_RS21700	4410973..4411266	+	294	WP_039515457.1	hypothetical protein	-
LJY16_RS21705	4412084..4412551	+	468	WP_000828178.1	sugar tyrosine-protein kinase	-
LJY16_RS21710	4412868..4413146	+	279	WP_077677834.1	hypothetical protein	-
LJY16_RS21715	4413213..4413527	-	315	WP_023892102.1	SymE family type I addiction module toxin	-
LJY16_RS21720	4413580..4414281	+	702	Protein_4155	integrase core domain-containing protein	-
LJY16_RS21725	4414980..4415543	+	564	WP_023993992.1	Saf-pilin pilus formation protein SafA	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	4387758..4433507	45749
	-	flank	IS/Tn	-	-	4414003..4414281	278

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9498.73 Da
• Isoelectric Point: 6.2112

>T222372 WP_023243487.1 NZ_CP085981:c4410639-4410382 [Salmonella enterica]
MNASGVSVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFETGRSVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T222372 NZ_CP117823:c2529365-2529066 [Xylella fastidiosa]
ATGACCTACACGCTAAAACGACTTGAAGGGTTCTCTGACTGGCTAAAGGGCCTAAAGGATGGGCTGGCAAGGCAGCGCCT
CATCAAGCGCTTACGCAAGGTGCAGCTCGGCAACTTTGGAGACGTGCAGCCGGTGGGTGAAGGCGTGTTTGAAATGCGCG
AACACTTCGGACCTGGCTGGCGTATGTACTACGTGCAGCGAGGCAGCTTTCTCATCGTGATGCTCGGCGGCGGCGACAAG
TCAACGCAGCAATCAGACATTCGTCGGGCCATTGAGCTAGCAAAATCTTTAGAGGATTGA

Antitoxin

Nucleotide

• Length: 333 bp

>AT222372 NZ_CP085981:4410464-4410796 [Salmonella enterica]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTCACGCTGCGCCCGGTCTCAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGA
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCTCGGCCAGCACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5I5SV33

Antitoxin