Detailed information of TA system
Overview
TA module
| Type | VII | Classification (family/domain) | TglT-TakA/AbiEii-AbiEi |
| Location | 1169378..1170879 | Replicon | chromosome |
| Accession | NZ_CP085532 | ||
| Organism | Mycobacterium tuberculosis variant bovis BCG strain Moreau PL | ||
Toxin (Protein)
| Gene name | tglT | Uniprot ID | L7N4P5 |
| Locus tag | LJF87_RS05585 | Protein ID | WP_003898703.1 |
| Coordinates | 1169998..1170879 (+) | Length | 294 a.a. |
Antitoxin (Protein)
| Gene name | takA | Uniprot ID | L7N5C7 |
| Locus tag | LJF87_RS05580 | Protein ID | WP_003405517.1 |
| Coordinates | 1169378..1170001 (+) | Length | 208 a.a. |
Genomic Context
| Locus tag | Coordinates | Strand | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| LJF87_RS05560 (LJF87_05520) | 1164873..1165700 | - | 828 | WP_003405370.1 | PE domain-containing protein | - |
| LJF87_RS05565 (LJF87_05525) | 1166488..1166727 | - | 240 | WP_003405375.1 | hypothetical protein | - |
| LJF87_RS05570 (LJF87_05530) | 1166896..1167823 | - | 928 | Protein_1097 | IS5-like element ISMt1 family transposase | - |
| LJF87_RS05575 (LJF87_05535) | 1168106..1169131 | - | 1026 | WP_011799149.1 | serine protease | - |
| LJF87_RS05580 (LJF87_05540) | 1169378..1170001 | + | 624 | WP_003405517.1 | type IV toxin-antitoxin system AbiEi family antitoxin domain-containing protein | Antitoxin |
| LJF87_RS05585 (LJF87_05545) | 1169998..1170879 | + | 882 | WP_003898703.1 | nucleotidyl transferase AbiEii/AbiGii toxin family protein | Toxin |
| LJF87_RS05590 (LJF87_05550) | 1171749..1172996 | + | 1248 | WP_003904572.1 | IS256-like element IS1081 family transposase | - |
| LJF87_RS05595 (LJF87_05555) | 1173364..1174479 | - | 1116 | WP_011799150.1 | hypothetical protein | - |
| LJF87_RS05600 (LJF87_05560) | 1174436..1174639 | - | 204 | WP_003405585.1 | hypothetical protein | - |
| LJF87_RS05605 (LJF87_05565) | 1174712..1175158 | + | 447 | WP_003405595.1 | oxidation-sensing regulator MosR | - |
Associated MGEs
| MGE detail |
Similar MGEs |
Relative position |
MGE Type | Cargo ARG | Virulence gene | Coordinates | Length (bp) |
|---|---|---|---|---|---|---|---|
| inside | IScluster/Tn | - | esxN | 1161242..1172996 | 11754 |
Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.
Sequences
Toxin
Download Length: 294 a.a. Molecular weight: 31958.65 Da Isoelectric Point: 6.3901
>T220865 WP_003898703.1 NZ_CP085532:1169998-1170879 [Mycobacterium tuberculosis variant bovis BCG]
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR
VTKPYSSPPTNLRSLRDRLTQVAERQGVVFGRLQRHVAMIVVAQFAATLTDDTGAPLLLVKGGSSLELRRGIPDSRTSKD
FDTVARRDIELIHEQLADAGETGWEGFTAIFTAPEEIDVPGMPVKPRRFTAKLSYRGRAFATVPIEVSSVEAGNADQFDT
LTSDALGLVGVPAAVAVPCMTIPWQIAQKLHAVTAVLEEPKVNDRAHDLVDLQLLEGLLLDADLMPTRSACIAIFEARAQ
HPWPPRVATLPHWPLIYAGALEGLDHLELARTVDAAAQAVQRFVARIDRATKR
Download Length: 882 bp
>T220865 NZ_CP117298:c2339587-2339153 [Mycobacterium tuberculosis variant bovis]
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA
ATGAAGATCGTCGACGCGAACGTCTTGCTCTACGCCGTGAACACCACAAGTGAGCACCACAAGCCGTCGCTGCGCTGGCT
TGACGGTGCGCTGTCGGGCGCCGACCGCGTCGGGTTCGCCTGGGTGCCGTTGTTGGCGTTCGTGCGATTGGCGACCAAGG
TGGGGTTGTTCCCCCGTCCGCTTCCGCGGGAGGCGGCCATCACCCAGGTCGCGGATTGGCTAGCCGCACCCAGCGCCGTC
TTGGTGAATCCGACCGTCCGGCACGCCGATATCCTGGCGAGAATGCTGACGTACGTGGGAACCGGTGCCAACCTGGTCAA
CGACGCGCATCTGGCCGCGCTTGCCGTCGAGCATCGCGCCAGCATCGTGTCCTACGACAGTGACTTCGGCCGATTCGAAG
GGGTGCGCTGGGATCAGCCGCCCGCGCTGTTGTGA
Antitoxin
Download Length: 208 a.a. Molecular weight: 22531.68 Da Isoelectric Point: 10.0518
>AT220865 WP_003405517.1 NZ_CP085532:1169378-1170001 [Mycobacterium tuberculosis variant bovis BCG]
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA
MCAKPYLIDTIAHMAIWDRLVEVAAEQHGYVTTRDARDIGVDPVQLRLLAGRGRLERVGRGVYRVPVLPRGEHDDLAAAV
SWTLGRGVISHESALALHALADVNPSRIHLTVPRNNHPRAAGGELYRVHRRDLQAAHVTSVDGIPVTTVARTIKDCVKTG
TDPYQLRAAIERAEAEGTLRRGSAAELRAALDETTAGLRARPKRASA
Download Length: 624 bp
>AT220865 NZ_CP117298:c2339848-2339594 [Mycobacterium tuberculosis variant bovis]
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG
ATGCGGACGACTGTCACATTGGATGACGACGTCGAGCAGTTGGTAAGGCGCCGGATGGCCGAGCGGCAAGTGTCCTTCAA
GAAGGCCCTCAACGACGCGATTCGCGACGGCGCCTCCGGGCGACCTGCGCCGAGTCACTTCAGCACCCGCACGGCAGACT
TGGGCGTCCCTGCGGTCAACCTCGACCGGGCCTTGCAGCTTGCGGCCGACCTCGAGGACGAAGAGCTTGTGCGCCGTCAA
CGCCGCGGGTCATAG
Similar Proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|