220022

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 4589806..4590218 Replicon chromosome
Accession NZ_CP084897
Organism Escherichia coli strain gb37

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag LHV64_RS22295 Protein ID WP_000132601.1
Coordinates 4589806..4590147 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 4590142..4590218 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHV64_RS22285 (4587219) 4587219..4588265 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
LHV64_RS22290 (4588265) 4588265..4589644 - 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
LHV64_RS22295 (4589806) 4589806..4590147 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- (4590142) 4590142..4590218 + 77 NuclAT_14 - Antitoxin
- (4590142) 4590142..4590218 + 77 NuclAT_14 - Antitoxin
- (4590142) 4590142..4590218 + 77 NuclAT_14 - Antitoxin
- (4590142) 4590142..4590218 + 77 NuclAT_14 - Antitoxin
- (4590142) 4590142..4590218 + 77 NuclAT_15 - Antitoxin
- (4590142) 4590142..4590218 + 77 NuclAT_15 - Antitoxin
- (4590142) 4590142..4590218 + 77 NuclAT_15 - Antitoxin
- (4590142) 4590142..4590218 + 77 NuclAT_15 - Antitoxin
LHV64_RS22300 (4590375) 4590375..4591769 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
LHV64_RS22305 (4591766) 4591766..4593355 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4582721..4591769 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T220022 WP_000132601.1 NZ_CP084897:c4590147-4589806 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

>T220022 NZ_CP116919:1120326-1120661 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCCGG
ACATCGTCCGGCTGTTGTCCTGAGTCCGTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACGGTTGCCCCAGAGGAATTACAGCTCATTAAAGCCAAAATTAA
CGTGCTGATTGGGTAG

Antitoxin


Download         Length: 77 bp

>AT220022 NZ_CP084897:4590142-4590218 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References