Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 4589807..4590219 Replicon chromosome
Accession NZ_CP084895
Organism Escherichia coli strain g74

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag LHV63_RS22295 Protein ID WP_000132601.1
Coordinates 4589807..4590148 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 4590143..4590219 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LHV63_RS22285 (4587220) 4587220..4588266 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
LHV63_RS22290 (4588266) 4588266..4589645 - 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
LHV63_RS22295 (4589807) 4589807..4590148 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- (4590143) 4590143..4590219 + 77 NuclAT_14 - Antitoxin
- (4590143) 4590143..4590219 + 77 NuclAT_14 - Antitoxin
- (4590143) 4590143..4590219 + 77 NuclAT_14 - Antitoxin
- (4590143) 4590143..4590219 + 77 NuclAT_14 - Antitoxin
- (4590143) 4590143..4590219 + 77 NuclAT_15 - Antitoxin
- (4590143) 4590143..4590219 + 77 NuclAT_15 - Antitoxin
- (4590143) 4590143..4590219 + 77 NuclAT_15 - Antitoxin
- (4590143) 4590143..4590219 + 77 NuclAT_15 - Antitoxin
LHV63_RS22300 (4590376) 4590376..4591770 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
LHV63_RS22305 (4591767) 4591767..4593356 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4582722..4591770 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T219936 WP_000132601.1 NZ_CP084895:c4590148-4589807 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

>T219936 NZ_CP116900:2446422-2446757 [Escherichia coli]
ATGGTAAGCCGATACGTACCCGATATGGGCGATCTGATTTGGGTTGATTTTGACCCGACAAAAGGTAGCGAGCAAGCTGG
ACATCGTCCAGCTGTTGTCCTGAGTCCTTTCATGTACAACAACAAAACAGGTATGTGTCTGTGTGTTCCTTGTACAACGC
AATCAAAAGGATATCCGTTCGAAGTTGTTTTATCCGGTCAGGAACGTGATGGCGTAGCGTTAGCTGATCAGGTAAAAAGT
ATCGCCTGGCGGGCAAGAGGAGCAACGAAGAAAGGAACAGTTGCCCCAGAGGAATTACAACTCATTAAAGCCAAAATTAA
CGTACTGATTGGGTAG

Antitoxin


Download         Length: 77 bp

>AT219936 NZ_CP084895:4590143-4590219 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References