Detailed information of TA system TA218170

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3694424..3694856
• Replicon: chromosome
• Accession: NZ_CP084194
• Organism: Salmonella sp. A39

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: E8XIW0
• Locus tag: LDO68_RS18260
• Protein ID: WP_000994224.1
• Coordinates: 3694581..3694856 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3694424..3694846 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LDO68_RS18230	3690642..3691379	-	738	WP_001535430.1	pili assembly chaperone SafB	-
LDO68_RS18235	3691463..3691975	-	513	WP_010988970.1	Saf-pilin pilus formation protein SafA	-
LDO68_RS18240	3692725..3693429	-	705	Protein_3564	integrase core domain-containing protein	-
LDO68_RS18245	3693482..3693730	+	249	WP_001738030.1	SymE family type I addiction module toxin	-
LDO68_RS18250	3693832..3694140	-	309	WP_080247984.1	hypothetical protein	-
LDO68_RS18255	3694223..3694396	-	174	WP_088131292.1	RHS repeat-associated core domain-containing protein	-
-	3694424..3694846	-	423	-	-	Antitoxin
LDO68_RS18260	3694581..3694856	+	276	WP_000994224.1	SymE family type I addiction module toxin	Toxin
LDO68_RS18265	3694909..3695346	-	438	WP_000943619.1	immunity 26/phosphotriesterase HocA family protein	-
LDO68_RS18270	3695909..3696355	-	447	WP_000935097.1	protein SciX	-
LDO68_RS18275	3696349..3697218	-	870	Protein_3571	polymorphic toxin type 47 domain-containing protein	-
LDO68_RS18280	3697282..3697545	-	264	WP_000932531.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3683572..3697545	13973
	-	flank	IS/Tn	-	-	3692725..3693006	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 10032.36 Da
• Isoelectric Point: 6.4704

>T218170 WP_000994224.1 NZ_CP084194:3694581-3694856 [Salmonella sp. A39]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWQEEAGFETGHGVTVKISEGCLILIAETDEVRDLRKELYQVKKSMKHI
KAGVNNVVNGD

Nucleotide

• Length: 276 bp

>T218170 NZ_CP115665:2700742-2701179 [Pseudomonas putida]
GTGATTTTGTGGCGAATCAGCGCCTATGCAGACTTGAGCGGTACGGGGGGCTTGCGTGTAAGTGGCCGCTGGCACCAGGC
GGGTCGGCCGGTGGTGTATGCCGCCACCAGCCCTCCTGGGGCGATGCTGGAAGTGTTGGTGCACCTGGAGATCGACCCCG
AGGATTTCCCTACCACCATGCGCTTGCTTCGCATCGAACTGCCCGACACGGTTTCCCAGGCGCAGTTGCCCGCTTTGCAG
CCCGGCTGGTCTGCTCAGCCTGAGTTGACCCGAACGCTGGGCAATCGCTTTCTGGATGACTGTTCGGCATTGCTGCTGCC
GGTGCCAAGCGCGATCATGCCCAGCACCACCAATTACCTGTTCAACCCACGGCACCCGCAGGCGCAGAGCGCGAAAATCC
AGGTTGAGGATTTCACGCCGGACAGCCGCCTGTTCTAG

Antitoxin

Nucleotide

• Length: 423 bp

>AT218170 NZ_CP084194:c3694846-3694424 [Salmonella sp. A39]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCCCTCAC
TTCGTCCGTCTCTGCAATCAGGATCAAACACCCCTCGGAGATCTTCACGGTGACGCCGTGCCCGGTCTCAAATCCCGCTT
CTTCCTGCCAGTCACCCTTAAGGTGCTGGCTGGGGATTTGTGAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATATGG
CGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTATTTATCCGCCGGATGCTGGCTGATTGTGGA
GCTCAGGGTGAGTGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGCCCCGGCCGGTGATGAGCA
GCCGGCTGCCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V2JPW5

Antitoxin