Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type II Classification (family/domain) pezAT/zeta-couple_hipB
Location 942415..943652 Replicon chromosome
Accession NC_008533
Organism Streptococcus pneumoniae D39

Toxin (Protein)


Gene name pezT Uniprot ID R4H7C0
Locus tag SPD_RS05015 Protein ID WP_000405357.1
Coordinates 942891..943652 (+) Length 254 a.a.

Antitoxin (Protein)


Gene name pezA Uniprot ID B6ZCC4
Locus tag SPD_RS05010 Protein ID WP_000579612.1
Coordinates 942415..942891 (+) Length 159 a.a.

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SPD_RS04985 (SPD_0925) 937488..938342 + 855 WP_000900020.1 ADP-ribosylglycohydrolase family protein -
SPD_RS04990 (SPD_0926) 938454..939338 + 885 WP_000710119.1 diacylglycerol kinase family lipid kinase -
SPD_RS04995 (SPD_0927) 939501..941240 + 1740 WP_000423451.1 glycoside hydrolase family 13 protein -
SPD_RS05000 (SPD_0928) 941326..941643 + 318 WP_000995820.1 hypothetical protein -
SPD_RS05005 (SPD_0929) 941689..941970 + 282 WP_000266233.1 hypothetical protein -
SPD_RS05010 (SPD_0930) 942415..942891 + 477 WP_000579612.1 helix-turn-helix domain-containing protein Antitoxin
SPD_RS05015 (SPD_0931) 942891..943652 + 762 WP_000405357.1 zeta toxin family protein Toxin
SPD_RS05020 (SPD_0932) 943680..944836 + 1157 Protein_931 hypothetical protein -
SPD_RS05030 (SPD_0934) 945668..946027 + 360 WP_000529543.1 hypothetical protein -
SPD_RS05035 (SPD_0935) 946037..946366 + 330 WP_000263037.1 MobC family plasmid mobilization relaxosome protein -
SPD_RS11335 946389..948274 + 1886 Protein_934 relaxase/mobilization nuclease domain-containing protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 927771..960532 32761


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Zeta toxin domain

(25-215)

Antitoxin

Cro/C1-type helix-turn-helix domain

(3-60)


Sequences

Toxin        


Download         Length: 254 a.a.        Molecular weight: 29044.10 Da        Isoelectric Point: 7.1307

>T21724 WP_000405357.1 NC_008533:942891-943652 [Streptococcus pneumoniae D39]
MEIQDYTDSEFKHALARNLRSLTRGKKSSKQPIAILLGGQSGAGKTTIHRIKQKEFQGNIVIIDGDSFRSQHPHYLELQQ
EYGKDSVEYTKDFAGKMVESLVTKLSSLGYNLLIEGTLRTIDVPKKTAQLLKNKGYEVQLALIATKPELSYLSTLIRYEE
LYIINPNQARATPKEHHDFIVNHLVDNTRKLEELAIFERIQIYQRDRSCVYDSKENTTSAADVLQELLFGEWSQVEKEML
QVGEKRLNELLEK

Download         Length: 762 bp

>T21724 NC_008533:942891-943652 [Streptococcus pneumoniae D39]
ATGGAAATCCAAGATTATACTGATAGTGAATTCAAACATGCTTTAGCAAGGAATCTTCGTTCACTGACAAGAGGAAAAAA
GTCCAGTAAACAACCTATAGCGATTTTGCTTGGAGGGCAAAGTGGTGCCGGTAAGACTACAATTCATCGTATTAAACAGA
AAGAATTTCAAGGAAATATTGTTATCATAGATGGCGATAGTTTTCGTTCTCAGCATCCACACTATTTAGAACTGCAGCAA
GAATATGGCAAAGATAGCGTTGAATACACCAAAGATTTTGCAGGAAAAATGGTAGAGTCTTTAGTAACAAAATTGAGTAG
TTTGGGATACAATCTTTTGATCGAGGGAACTTTACGAACAATTGATGTTCCAAAGAAAACGGCACAACTCTTGAAAAATA
AGGGATATGAAGTACAATTGGCCTTAATTGCGACAAAGCCTGAATTGTCGTATCTAAGTACTCTTATCCGTTATGAAGAA
CTGTACATTATCAATCCAAATCAAGCACGCGCAACTCCAAAAGAACATCATGATTTCATTGTAAATCATCTAGTTGATAA
CACACGAAAATTGGAAGAACTAGCTATCTTTGAAAGAATTCAAATTTACCAACGAGATAGAAGTTGTGTATATGATTCAA
AAGAAAATACAACTTCAGCAGCAGATGTTCTTCAAGAGTTACTCTTTGGGGAGTGGAGTCAGGTAGAGAAGGAGATGTTG
CAGGTGGGGGAAAAGAGACTTAATGAATTACTTGAAAAATAA

Antitoxin


Download         Length: 159 a.a.        Molecular weight: 18245.68 Da        Isoelectric Point: 4.4188

>AT21724 WP_000579612.1 NC_008533:942415-942891 [Streptococcus pneumoniae D39]
MIGKNIKSLRKTHDLTQPEFARIIGISRNSLSRYENGTSSVSTELIDIICQKFNVSYVDIVGEDKMLNPVEDYELTLKIE
IVKERGANLLSRLYRYQDSQGISIDDESNPWILMSDDLSDLIHTNIYLVETFDEIERYSGYLDGIERMLEISEKRMVA

Download         Length: 477 bp

>AT21724 NC_008533:942415-942891 [Streptococcus pneumoniae D39]
ATGATTGGAAAGAACATAAAATCCTTACGTAAAACACATGACTTAACACAACCCGAATTTGCACGAATTATAGGAATTTC
TCGAAATAGCTTGAGTCGTTATGAAAATGGAACTAGTTCAGTCTCTACAGAATTAATTGACATCATTTGTCAGAAGTTTA
ATGTATCTTATGTCGATATTGTAGGAGAAGATAAAATGCTCAATCCTGTTGAAGATTATGAATTGACTTTGAAAATTGAA
ATTGTGAAAGAAAGAGGTGCTAATCTATTATCTCGACTCTATCGTTATCAAGATAGTCAGGGAATTAGCATTGATGATGA
ATCTAATCCTTGGATTTTAATGAGTGATGATCTATCTGACTTGATTCATACGAATATCTATTTAGTAGAAACTTTTGATG
AAATAGAGAGATATAGTGGCTATTTGGATGGAATTGAACGTATGTTAGAGATATCTGAAAAGCGGATGGTAGCTTAA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB R4H7C0

Antitoxin

Source ID Structure
AlphaFold DB B6ZCC4

References