Detailed information of TA system TA217190

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3600655..3601069
• Replicon: chromosome
• Accession: NZ_CP083731
• Organism: Salmonella sp. A29-2

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A3V3U6I8
• Locus tag: K8W53_RS17590
• Protein ID: WP_023203422.1
• Coordinates: 3600812..3601069 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3600655..3600987 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8W53_RS17560	3595912..3596409	-	498	WP_058654878.1	Saf-pilin pilus formation protein SafA	-
K8W53_RS17565	3597170..3597874	-	705	Protein_3429	integrase core domain-containing protein	-
K8W53_RS17570	3597927..3598163	+	237	Protein_3430	type I toxin-antitoxin system SymE family toxin	-
K8W53_RS17575	3598308..3598586	-	279	WP_012664366.1	hypothetical protein	-
K8W53_RS17580	3598904..3599371	-	468	WP_000828182.1	sugar tyrosine-protein kinase	-
K8W53_RS17585	3599464..3599739	-	276	WP_223163371.1	hypothetical protein	-
-	3600655..3600987	-	333	-	-	Antitoxin
K8W53_RS17590	3600812..3601069	+	258	WP_023203422.1	SymE family type I addiction module toxin	Toxin
K8W53_RS17595	3601128..3601436	-	309	WP_023203423.1	hypothetical protein	-
K8W53_RS17600	3601455..3601862	-	408	WP_024146273.1	DUF4329 domain-containing protein	-
K8W53_RS17605	3602223..3602744	-	522	WP_023203424.1	SMI1/KNR4 family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3578679..3634646	55967
	-	flank	IS/Tn	-	-	3597170..3597451	281

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-56)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9439.71 Da
• Isoelectric Point: 7.2431

>T217190 WP_023203422.1 NZ_CP083731:3600812-3601069 [Salmonella sp. A29-2]
MNASGASVRHINSETCMTTSYSHIPSQHLKGDWQEEAGFKTGRGVTVKISQGCIVLMADSNEEQKLREQLYKAEQVVKGM
RDVIV

Nucleotide

• Length: 258 bp

>T217190 NZ_CP113974:219816-220403 [Pseudomonas aeruginosa]
ATGTCGAGGAGGGCGCCCATGTTCAAGCCGCTACCGATCACCCTGCAGCGCGGAGCCTTGCGTCTCGAGCCGCTGGTGGA
AGCGGACATTCCCGAGCTGGTGAGCCTCGCCGAAGCCAACCGCGAGGCGCTGCAGTACATGGACGGACCGACGCGGCCGG
ACTGGTACCGCCAGAGCCTCGCCGAGCAGCGCGAGGGCAGGGCGTTGCCGCTCGCCGTCCGCCTCGGCGTGCAACTGGTC
GGGACCACGCGCTTCGCCGAATTCCTTCCCGCCTTGCCGGCCTGCGAGATCGGCTGGACCTGGCTCGACCAGGCCCAGCA
CGGCAGCGGCCTGAACCGCATGATCAAGTACCTGATGCTCAAGCATGCCTTCGACAACCTGCGCATGGTCCGCGTGCAGC
TCAGCACGGCGGCGAGCAACCTGCGCGCCCAGGGCGCCATCGACAAGCTCGGCGCGCAGCGCGAGGGCGTGCTGCGCAAC
CACCGGCGGCTGGCCGGCGGGCGGCTAGACGACACCTTCGTCTACAGCATCACCGACCACGAATGGCCGCAGGTCAAGGC
GGCGCTGGAAGCCAGCTTCACCGGCTGA

Antitoxin

Nucleotide

• Length: 333 bp

>AT217190 NZ_CP083731:c3600987-3600655 [Salmonella sp. A29-2]
TCCGCCATCAGCACAATACACCCCTGTGAAATCTTCACGGTGACGCCGCGCCCGGTCTTAAATCCCGCTTCTTCCTGCCA
GTCACCCTTAAGGTGCTGGCTGGGGATATGTGAGTAACTGGTGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGG
CGCCGGAGGCATTCATATTTGCTGACTAAATAAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTTAGGGTG
AGCGAGTATGGGCGCGACATCCTGGCACCGCGCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACC
GGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A3V3U6I8

Antitoxin