Detailed information of TA system TA217039

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 4706909..4707166
• Replicon: chromosome
• Accession: NZ_CP083651
• Organism: Citrobacter amalonaticus strain FDAARGOS_1489

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: -
• Locus tag: LA348_RS22405
• Protein ID: WP_224267567.1
• Coordinates: 4706909..4707166 (+)
• Length: 86 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	4706938..4707156 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
LA348_RS22385 (LA348_22385)	4702080..4703939	+	1860	WP_054177121.1	bifunctional glutathionylspermidine amidase/synthase	-
LA348_RS22390 (LA348_22390)	4704714..4704866	-	153	WP_231912847.1	replication initiation protein	-
LA348_RS22395 (LA348_22395)	4705371..4705910	+	540	WP_044255706.1	hypothetical protein	-
LA348_RS22400 (LA348_22400)	4706078..4706936	+	859	Protein_4365	IS3 family transposase	-
LA348_RS22405 (LA348_22405)	4706909..4707166	+	258	WP_224267567.1	SymE family type I addiction module toxin	Toxin
-	4706938..4707156	-	219	-	-	Antitoxin
LA348_RS22410 (LA348_22410)	4707217..4707537	-	321	WP_061070583.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (11-50)

Sequences

Toxin

Protein

• Length: 86 a.a.
• Molecular weight: 9414.82 Da
• Isoelectric Point: 8.5042

>T217039 WP_224267567.1 NZ_CP083651:4706909-4707166 [Citrobacter amalonaticus]
MGRATCSKTHMTTYYSRIPSLHLKGDWLAEAGFDTGASVTVKISEGCLTLIVETDEVRDLRKELYQVKKSMKHIKAGVNN
VVNGD

Nucleotide

• Length: 258 bp

>T217039 NZ_CP113541:3433871-3434089 [Salmonella enterica]
ATGTCTGATAAACCATTAACTAAAACTGATTATTTGATGCGTTTACGGCGCTGTCAGACAATTGACACTCTGGAGCGCGT
CATTGAGAAAAATAAATATGAATTGTCCGACAATGAGCTGGCTGTATTTTACTCAGCTGCGGATCACCGTCTTGCAGAAT
TGACGATGAACAAACTCTACGACAAGATCCCCTCTTCAGTATGGAAATTCATTCGTTAA

Antitoxin

Nucleotide

• Length: 219 bp

>AT217039 NZ_CP083651:c4707156-4706938 [Citrobacter amalonaticus]
TTCACCACATTATTTACCCCCGCCTTAATATGCTTCATCGACTTTTTCACCTGATAAAGCTCCTTCCGTAGATCTCTCAC
TTCGTCTGTCTCCACAATCAGAGTCAAACACCCCTCGGAGATCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTT
CTGCCAGCCAGTCACCCTTGAGATGCAGACTGGGAATGCGTGAGTAATAGGTGGTCATG

Structures

Antitoxin