Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 15467..15725 Replicon chromosome
Accession NC_008258
Organism Shigella flexneri 5 str. 8401

Toxin (Protein)


Gene name hokC Uniprot ID S1NX00
Locus tag SFV_RS00080 Protein ID WP_000809168.1
Coordinates 15467..15619 (-) Length 51 a.a.

Antitoxin (RNA)


Gene name sokC
Locus tag -
Coordinates 15668..15725 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
SFV_RS00060 10708..11421 - 714 WP_001102352.1 acidic protein MsyB -
SFV_RS00065 11447..11851 - 405 WP_000843568.1 DUF2541 family protein -
SFV_RS00070 12228..14144 + 1917 WP_000516121.1 molecular chaperone DnaK -
SFV_RS00075 14233..15363 + 1131 WP_001118475.1 molecular chaperone DnaJ -
SFV_RS00080 15467..15619 - 153 WP_000809168.1 type I toxin-antitoxin system toxin MokC Toxin
- 15668..15725 + 58 - - Antitoxin
SFV_RS00085 16206..17372 + 1167 WP_000681350.1 Na+/H+ antiporter NhaA -
SFV_RS00090 17438..18337 + 900 WP_001338226.1 transcriptional activator NhaR -
SFV_RS00095 18375..18734 - 360 Protein_17 fimbrial family protein -
SFV_RS00100 18750..19447 - 698 Protein_18 IS1 family transposase -
SFV_RS00110 19836..20099 - 264 WP_001274023.1 30S ribosomal protein S20 -
SFV_RS00115 20202..20420 + 219 WP_011110533.1 DUF2575 family protein -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
flank IS/Tn - - 18750..19253 503


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 51 a.a.        Molecular weight: 5501.57 Da        Isoelectric Point: 7.1312

>T21643 WP_000809168.1 NC_008258:c15619-15467 [Shigella flexneri 5 str. 8401]
MKQHKAMIVALIVICITAVVAALVTRKDLCEVHIRTGQTEVAVFTAYESE

Download         Length: 153 bp

>T21643 NC_008258:c15619-15467 [Shigella flexneri 5 str. 8401]
ATGAAGCAGCATAAGGCGATGATTGTCGCCCTGATCGTCATCTGTATCACCGCCGTAGTGGCGGCGCTGGTAACGAGAAA
AGACCTCTGTGAGGTTCACATCCGAACTGGCCAGACGGAGGTTGCTGTTTTCACGGCTTACGAATCCGAGTAA

Antitoxin


Download         Length: 58 bp

>AT21643 NC_008258:15668-15725 [Shigella flexneri 5 str. 8401]
GTTCAGCATATAGGGGGCCTCGGGTTGATGGTAAAATATCACTCGGGGCTTTTCTCTA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB S1NX00

Antitoxin

Download structure file

References