Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) symE-ohsC/SymE(toxin)
Location 4579363..4579775 Replicon chromosome
Accession NZ_CP083410
Organism Escherichia coli strain RP437

Toxin (Protein)


Gene name symE Uniprot ID U9YSY7
Locus tag LAJ62_RS22210 Protein ID WP_000132601.1
Coordinates 4579363..4579704 (-) Length 114 a.a.

Antitoxin (RNA)


Gene name ohsC
Locus tag -
Coordinates 4579699..4579775 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
LAJ62_RS22200 (4576776) 4576776..4577822 - 1047 WP_000437621.1 5-methylcytosine-specific restriction endonuclease system specificity protein McrC -
LAJ62_RS22205 (4577822) 4577822..4579201 - 1380 WP_000443951.1 5-methylcytosine-specific restriction endonuclease subunit McrB -
LAJ62_RS22210 (4579363) 4579363..4579704 - 342 WP_000132601.1 endoribonuclease SymE Toxin
- (4579699) 4579699..4579775 + 77 NuclAT_14 - Antitoxin
- (4579699) 4579699..4579775 + 77 NuclAT_14 - Antitoxin
- (4579699) 4579699..4579775 + 77 NuclAT_14 - Antitoxin
- (4579699) 4579699..4579775 + 77 NuclAT_14 - Antitoxin
- (4579699) 4579699..4579775 + 77 NuclAT_15 - Antitoxin
- (4579699) 4579699..4579775 + 77 NuclAT_15 - Antitoxin
- (4579699) 4579699..4579775 + 77 NuclAT_15 - Antitoxin
- (4579699) 4579699..4579775 + 77 NuclAT_15 - Antitoxin
LAJ62_RS22215 (4579932) 4579932..4581326 - 1395 WP_001272447.1 type I restriction-modification system specificity subunit -
LAJ62_RS22220 (4581323) 4581323..4582912 - 1590 WP_001063204.1 type I restriction-modification system methyltransferase -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Genomic island - - 4572278..4581326 9048


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Toxin SymE-like

(20-71)


Sequences

Toxin        


Download         Length: 114 a.a.        Molecular weight: 12203.02 Da        Isoelectric Point: 8.5012

>T216394 WP_000132601.1 NZ_CP083410:c4579704-4579363 [Escherichia coli]
MTDTHSIAQPFEAEVSPANNRHVTVGYASRYPDYSRIPAITLKGQWLEAAGFATGTAVDVKVMEGCIVLTAQPPAAEESE
LMQSLRQVCKLSARKQKQVQAFIGVIAGKQKVA

Download         Length: 342 bp

>T216394 NZ_CP113037:2375834-2376022 [Staphylococcus aureus]
ATGTCTTTACATTTTGCAATTCTGTTTTGGCTAGCATTAATTTTCTTAGTTGCCGCTACGTTTATACTCGTATTAATGAA
AAAAACTGGCAAAGAATCTAAAAAAGAGTCCTATTTAAGTTTCACTGTCATTCTCTATATATTCGGATTCGCTATATTAA
TATACACATTTATATTTGGTGTGCTATAA

Antitoxin


Download         Length: 77 bp

>AT216394 NZ_CP083410:4579699-4579775 [Escherichia coli]
AGTCATAACTGCTATTCTCCAGGAATAGTGATTGTGATTAGCGATGCGGGTGTGTTGGCGCACATCCGCACCGCGCT

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB U9YSY7

Antitoxin

Download structure file

References