Detailed information of TA system TA215644

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): IasE-IsrA/SymE(toxin)
• Location: 3556149..3556581
• Replicon: chromosome
• Accession: NZ_CP082929
• Organism: Salmonella enterica subsp. enterica serovar London isolate N18-04674

Toxin (Protein)

• Gene name: IasE
• Uniprot ID: A0A5H8VGI7
• Locus tag: K6991_RS17300
• Protein ID: WP_058805824.1
• Coordinates: 3556306..3556581 (+)
• Length: 92 a.a.

Antitoxin (RNA)

Gene name	IsrA
Locus tag	-
Coordinates	3556149..3556530 (-)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K6991_RS17270	3551412..3551906	-	495	WP_058805823.1	pilus assembly protein	-
K6991_RS17275	3552671..3553372	-	702	Protein_3380	integrase core domain-containing protein	-
K6991_RS17280	3553425..3553739	+	315	WP_011233128.1	SymE family type I addiction module toxin	-
K6991_RS17285	3553806..3554084	-	279	WP_077905025.1	hypothetical protein	-
K6991_RS17290	3554400..3554867	-	468	WP_000828173.1	sugar tyrosine-protein kinase	-
K6991_RS17295	3555739..3555972	-	234	WP_129374720.1	hypothetical protein	-
-	3556149..3556530	-	382	-	-	Antitoxin
K6991_RS17300	3556306..3556581	+	276	WP_058805824.1	SymE family type I addiction module toxin	Toxin
K6991_RS17305	3556626..3556943	-	318	WP_129374721.1	hypothetical protein	-
K6991_RS17310	3556909..3558192	-	1284	Protein_3387	RHS domain-containing protein	-
K6991_RS17315	3558329..3558793	-	465	WP_223152163.1	hypothetical protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)
	-	inside	Genomic island	-	-	3543516..3584473	40957

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

• Toxin SymE-like (14-57)

Sequences

Toxin

Protein

• Length: 92 a.a.
• Molecular weight: 9901.27 Da
• Isoelectric Point: 5.0770

>T215644 WP_058805824.1 NZ_CP082929:3556306-3556581 [Salmonella enterica subsp. enterica serovar London]
MNASGVSVRHINSETCMTACYSQIPSQHLKGDWLAEAGFDTGASVTVKSSEGCLTLIAERDEVQELREELYQVKQVVKGM
KVGISGVLREV

Nucleotide

• Length: 276 bp

>T215644 NZ_CP110859:c3891657-3891307 [Escherichia coli]
ATGGTAAAGAAAAGTGAATTTGAACGGGGAGACATTGTGCTGGTTGGCTTTGATCCAGCAAGCGGCCATGAACAGCAAGG
TGCTGGTCGACCTGCGCTTGTGCTCTCCGTTCAAGCCTTTAATCAACTGGGAATGACGCTGGTGGCCCCCATTACGCAGG
GCGGAAATTTTGCCCGTTATGCCGGATTTAGCGTTCCTTTACATTGCGAAGAAGGCGATGTGCACGGCGTGGTGCTGGTG
AATCAGGTGCGGATGATGGATCTACACGCCCGGCTGGCAAAGCGTATTGGTCTGGCTGCGGATGAGGTGGTGGAAGAGGC
GTTATTACGCTTGCAGGCGGTGGTGGAATAA

Antitoxin

Nucleotide

• Length: 382 bp

>AT215644 NZ_CP082929:c3556530-3556149 [Salmonella enterica subsp. enterica serovar London]
CTGTTTAACCTGATAAAGTTCCTCCCGCAGCTCCTGCACCTCGTCGCGCTCCGCAATCAGAGTCAAACACCCCTCGGAGC
TCTTCACGGTCACGCTCGCCCCGGTATCAAATCCCGCTTCTGCCAGCCAGTCGCCCTTAAGGTGCTGGCTGGGGATTTGT
GAGTAACAGGCGGTCATGCAGGTTTCGCTGTTGATGTGGCGGACGCTGACGCCGGAGGCATTCATATTTGCTGACTAAAT
AAATTCTTAATTCTCCGCCGGATGCTGGCTGATTGTGGAGCTCAGGGTGAGCGAGTATGGGCGCGACATCCTGGCACCGC
GCCTCCCTCTCCCCGGCCAGTACCGGGCGGTGATGAGCAACCGGCTACCGGGGCCGTATTTT

Structures

Toxin

• AlphaFold DB: A0A5H8VGI7

Antitoxin