Detailed information of TA system TA215485

Bioinformatically predicted

Overview

TA module

• Type: I
• Classification (family/domain): CD-RCd/-
• Location: 357157..357353
• Replicon: chromosome
• Accession: NZ_CP082868
• Organism: Clostridioides difficile strain FDAARGOS_1469

Toxin (Protein)

• Gene name: CD1418.2
• Uniprot ID: D5Q3X5
• Locus tag: K8P06_RS01755
• Protein ID: WP_003424190.1
• Coordinates: 357201..357353 (-)
• Length: 51 a.a.

Antitoxin (RNA)

Gene name	CD630_n00500
Locus tag	-
Coordinates	357157..357257 (+)

Genomic Context

Locus tag	Coordinates	Strand	Size (bp)	Protein ID	Product	Description
K8P06_RS01730 (353165)	353165..353359	-	195	WP_003424168.1	hypothetical protein	-
K8P06_RS19085 (353756)	353756..353890	-	135	WP_003424178.1	hypothetical protein	-
K8P06_RS01735 (353896)	353896..354255	-	360	WP_009905664.1	hypothetical protein	-
K8P06_RS01740 (354269)	354269..354526	-	258	WP_003424182.1	hypothetical protein	-
K8P06_RS01745 (354513)	354513..354746	-	234	WP_003424184.1	hypothetical protein	-
K8P06_RS01750 (354934)	354934..355122	+	189	WP_003424185.1	helix-turn-helix transcriptional regulator	-
K8P06_RS19090 (355325)	355325..355456	-	132	WP_003424186.1	hypothetical protein	-
- (357157)	357157..357257	+	101	NuclAT_0	-	Antitoxin
- (357157)	357157..357257	+	101	NuclAT_0	-	Antitoxin
- (357157)	357157..357257	+	101	NuclAT_0	-	Antitoxin
K8P06_RS01755 (357201)	357201..357353	-	153	WP_003424190.1	hypothetical protein	Toxin
K8P06_RS01760 (358196)	358196..358726	+	531	WP_003424192.1	site-specific integrase	-
K8P06_RS01765 (359271)	359271..360116	+	846	WP_003424194.1	DUF4878 domain-containing protein	-
K8P06_RS01770 (360340)	360340..360504	-	165	WP_003424195.1	hypothetical protein	-
K8P06_RS01775 (361036)	361036..361227	-	192	WP_003424196.1	carboxymuconolactone decarboxylase family protein	-
K8P06_RS01780 (361227)	361227..361367	-	141	WP_003424197.1	hypothetical protein	-
K8P06_RS01785 (361627)	361627..361830	-	204	WP_022616047.1	SdpI family protein	-

Associated MGEs

MGE detail	Similar MGEs	Relative position	MGE Type	Cargo ARG	Virulence gene	Coordinates	Length (bp)

Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.

Domains

Predicted by InterproScan

Toxin

No domain identified.

Sequences

Toxin

Protein

• Length: 51 a.a.
• Molecular weight: 5744.78 Da
• Isoelectric Point: 10.6276

>T215485 WP_003424190.1 NZ_CP082868:c357353-357201 [Clostridioides difficile]
MDNFLQGILASLVASLIVYLTSKLFKKVKSHSGRSDFSFELEIKFKKNKH

Nucleotide

• Length: 153 bp

>T215485 NZ_CP110789:835796-836224 [Yersinia intermedia]
GTGGCCCAGTGGCGATGTGACTTGCGGGTATCCTGGCACACTCAACTCTTCTCTTTATTGTCTCATGGTGTTTTGGTCAT
ACTCACCTTGGTTGCACCCTGGCCCCAGGGGTATACCGCACTGTGGTTGGTATTGCTGACGCTGGTAGTGTTTGAGTGTA
TCCGCAGCCAGAAAAATATTACGTCCTGTCAAGGCGAGATCCGGCTGAAACCCGGTAACCTGGTTCTATGGAAAAGGTTC
GAATGGATCGTGGTCAAACAGCCATGGATTACCCGTTATGGCGTGTTATTAAATCTACAGCAGTCGAGCAGCCGTTCAGC
CCGTAAGCGGTTGTGGCTGGCCGCCGACAGTATGTCAGAAGATGAGTGGCGGCAATTATGTCAGCTATTGCGGCATTCAT
TTGGCTCAGATAAAGGTATGAATCAATGA

Antitoxin

Nucleotide

• Length: 101 bp

>AT215485 NZ_CP082868:357157-357257 [Clostridioides difficile]
AAGAAGAACTACAATCTATTTAGACGTAGAGTGAAGTTCAAATACTAATGTTTATTCTTTTTGAACTTGATTTCTAGTTC
AAAACTAAAGTCACTCCTGCC

Structures

Toxin

• AlphaFold DB: A0A449XCJ1

Antitoxin