215373

Detailed information of TA system    

insolicoBioinformatically predicted

Overview

TA module


Type I Classification (family/domain) hok-sok/-
Location 2118767..2118992 Replicon chromosome
Accession NZ_CP082835
Organism Escherichia coli strain 1613

Toxin (Protein)


Gene name hokW Uniprot ID A0A1Q4PF16
Locus tag K8O78_RS10450 Protein ID WP_000813258.1
Coordinates 2118767..2118922 (-) Length 52 a.a.

Antitoxin (RNA)


Gene name sokW
Locus tag -
Coordinates 2118934..2118992 (+)

Genomic Context

Locus tag Coordinates Strand Size (bp) Protein ID Product Description
K8O78_RS10400 2113770..2114201 - 432 WP_001302123.1 tellurite resistance protein -
K8O78_RS10415 2114652..2115365 - 714 WP_000301797.1 helix-turn-helix domain-containing protein -
K8O78_RS10420 2115501..2115698 - 198 WP_000917763.1 hypothetical protein -
K8O78_RS10425 2115923..2116477 - 555 WP_000640035.1 DUF1133 family protein -
K8O78_RS10430 2116540..2116845 - 306 WP_001217444.1 RusA family crossover junction endodeoxyribonuclease -
K8O78_RS10435 2116858..2117907 - 1050 WP_001265229.1 DUF968 domain-containing protein -
K8O78_RS10440 2117909..2118181 - 273 WP_000191872.1 hypothetical protein -
K8O78_RS10445 2118303..2118647 - 345 WP_000756596.1 YgiW/YdeI family stress tolerance OB fold protein -
K8O78_RS10450 2118767..2118922 - 156 WP_000813258.1 Hok/Gef family protein Toxin
- 2118934..2118992 + 59 - - Antitoxin
K8O78_RS10455 2119213..2119770 - 558 WP_000104474.1 DUF551 domain-containing protein -
K8O78_RS10460 2119772..2119990 - 219 WP_000683609.1 DUF4014 family protein -
K8O78_RS10465 2120118..2120429 - 312 WP_001289673.1 hypothetical protein -
K8O78_RS10470 2120422..2120649 - 228 WP_000699809.1 hypothetical protein -
K8O78_RS10475 2120646..2120927 - 282 WP_000603384.1 DNA-binding protein -
K8O78_RS10480 2120960..2121676 - 717 WP_000450627.1 DUF1627 domain-containing protein -
K8O78_RS10485 2121710..2122171 - 462 WP_000139447.1 replication protein P -
K8O78_RS10490 2122164..2123207 - 1044 WP_001262402.1 DnaT-like ssDNA-binding domain-containing protein -
K8O78_RS10495 2123276..2123701 - 426 WP_000693878.1 toxin YdaT family protein -
K8O78_RS10500 2123685..2123927 - 243 WP_000747948.1 Cro/CI family transcriptional regulator -

Associated MGEs

MGE
detail		 Similar
MGEs		 Relative
position		 MGE Type Cargo ARG Virulence gene Coordinates Length (bp)
inside Prophage - nleG7' 2081662..2180761 99099


Relative position:
(1) inside: TA loci is completely located inside the MGE;
(2) overlap: TA loci is partially overlapped with the MGE;
(3) flank: The TA loci is located in the 5 kb flanking regions of MGE.


Domains

Predicted by InterproScan

Toxin

Hok/gef cell toxic protein

(6-47)


Sequences

Toxin        


Download         Length: 52 a.a.        Molecular weight: 5767.95 Da        Isoelectric Point: 7.7942

>T215373 WP_000813258.1 NZ_CP082835:c2118922-2118767 [Escherichia coli]
MKQQKAMLIALIVICLTVIVTALVTRKDLCEVRIRTGQTEVAVFVDYESEK

Download         Length: 156 bp

>T215373 NZ_CP110664:1503344-1503604 [Actinobacillus pleuropneumoniae]
ATGAAGCTAACTTTCTCGTCTAATGCGTGGGAAGATTATTTATACTGGCAAAAAACCGATAAAATAATTTTGAAACGTAT
AAACAGCCTGATCAAAGATATTCAACGCCAACCATTCGAAGGCATAGGAAAACTGGAGCCGCTAAAATTCAATCTTTCGG
GATTTTGGTCAAGGCGAATCAATGAAGAACACCGCTTAATTTACAGCGTGGAAGATGAAGCAATTTTAATAGTAGCGTGT
AGATACCATTATGATCAGTAA

Antitoxin


Download         Length: 59 bp

>AT215373 NZ_CP082835:2118934-2118992 [Escherichia coli]
CCTTGCCTTTCGGCACGTAAGAGGCTAACCTACATGTGTTCAGCATGGATTGAGCCTCA

Similar Proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
Protein Organism Identities (%) Coverage (%) Ha-value

Structures

Toxin

Source ID Structure
AlphaFold DB A0A1Q4PF16

Antitoxin

Download structure file

References